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However, pediatric\u2010inspired chemotherapy may also offer durable leukemia\u2010free survival in the absence of HCT. We compared 422 HCT recipients aged 18\u201350 years with Ph\u2010ALL in CR1 reported to the CIBMTR with an age\u2010matched concurrent cohort of 108 Ph\u2212 ALL CR1 patients who received a Dana\u2010Farber Consortium pediatric\u2010inspired non\u2010HCT regimen. At 4 years of follow\u2010up, incidence of relapse after HCT was 24% (95% CI 19\u201328) versus 23% (95% CI 15\u201332) for the non\u2010HCT (chemo) cohort (<jats:italic>P<\/jats:italic>=0.97). Treatment\u2010related mortality (TRM) was higher in the HCT cohort [HCT 37% (95% CI 31\u201342) versus chemo 6% (95% CI 3\u201312), <jats:italic>P<\/jats:italic>&lt;0.0001]. DFS in the HCT cohort was 40% (95% CI 35\u201345) versus 71% (95% CI 60\u201379) for chemo, <jats:italic>P<\/jats:italic>&lt;0.0001. Similarly, OS favored chemo [HCT 45% (95% CI 40\u201350)] versus chemo 73% [(95% CI 63\u201381), <jats:italic>P<\/jats:italic>&lt;0.0001]. In multivariable analysis, the sole factor predictive of shorter OS was the administration of HCT [hazard ratio 3.12 (1.99\u20134.90), <jats:italic>P<\/jats:italic>&lt;0.0001]. For younger adults with Ph\u2212 ALL, pediatric\u2010inspired chemotherapy had lower TRM, no increase in relapse, and superior overall survival compared to HCT. Am. J. Hematol. 91:322\u2013329, 2016. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24285","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T16:21:22Z","timestamp":1450887682000},"page":"322-329","source":"Crossref","is-referenced-by-count":79,"title":["Pediatric\u2010inspired therapy compared to allografting for <scp>P<\/scp>hiladelphia chromosome\u2010negative adult ALL in first complete remission"],"prefix":"10.1002","volume":"91","author":[{"given":"Matthew D.","family":"Seftel","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Haematology CancerCare Manitoba Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Neuberg","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology Dana\u2010Farber Cancer Institute Boston Massachutsetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research (CIBMTR<sup>\u00ae<\/sup>), Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin"},{"name":"Medical College of Wisconsin, Division of Biostatistics Institute for Health and Society Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research (CIBMTR<sup>\u00ae<\/sup>), Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Kuhn","family":"Ballen","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bergeron","sequence":"additional","affiliation":[{"name":"Department of Hematology H\u00f4pital Maisonneuve\u2010Rosemont Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Couban","sequence":"additional","affiliation":[{"name":"Division of Haematology Queen Elizabeth II Health Sciences Centre, Dalhousie University Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar O.","family":"Freytes","sequence":"additional","affiliation":[{"name":"South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Hamadani","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research (CIBMTR<sup>\u00ae<\/sup>), Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Kharfan\u2010Dabaja","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation H. Lee Moffitt Cancer Center and Research Institute Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillard M.","family":"Lazarus","sequence":"additional","affiliation":[{"name":"Department of Medicine Seidman Cancer Center, University Hospitals Case Medical Center Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiga","family":"Nishihori","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation H. Lee Moffitt Cancer Center and Research Institute Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristjan","family":"Paulson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Haematology CancerCare Manitoba Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Saber","sequence":"additional","affiliation":[{"name":"Center for International Blood and Marrow Transplant Research (CIBMTR<sup>\u00ae<\/sup>), Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen E.","family":"Sallan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Soiffer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology\/Hematologic Malignancies Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S.","family":"Tallman","sequence":"additional","affiliation":[{"name":"Department of Medicine Leukemia Service, Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann E.","family":"Woolfrey","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematopoietic Cell Transplant Fred Hutchinson Cancer Research Center Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"DeAngelo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology\/Hematologic Malignancies Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Weisdorf","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Transplantation, Department of Medicine University of Minnesota Medical Center Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Acute Leukemia Committee of the CIBMTR and the Dana Farber ALL Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27617"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25319"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116582"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.253"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.6397"},{"key":"e_1_2_6_7_1","first-page":"CD008818","article-title":"Allogeneic hematopoietic cell transplantation for adult acute lymphoblastic leukemia (ALL) in first complete remission","author":"Pidala J","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.09.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-445098"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-128918"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-269571"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.229"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.6916"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2014.72"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.10.025"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","unstructured":"StockW LugerS AdvaniAS et al. 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