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Disagreements concerning the WHO classification are mainly focused on the discrimination between essential thrombocythemia (ET) and prefibrotic\/early primary myelofibrosis (prePMF) and prodromal polycythemia vera (PV). Criticism mostly refers to lack of standardization of distinctive BM features precluding correct morphological pattern recognition. The distinction between WHO\u2010defined ET and prePMF is not trivial because outcome is significantly worse in prePMF. Morphology was generally considered to be non\u2010specific for the diagnosis of PV. Recent studies have revealed under\u2010diagnosis of morphologically and biologically consistent PV. Am. J. 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