{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:19:26Z","timestamp":1778228366825,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Molecular predictors of outcome are increasingly important in determining optimal therapy for myeloid neoplasms. Mutations in the spliceosomal genes (<jats:italic>U2AF1<\/jats:italic> and <jats:italic>SRSF2<\/jats:italic>) predict for poor outcomes in myelodysplastic syndromes (MDS) and related diseases. We investigated the effect of hematopoietic cell transplant (HCT) on the negative prognostic impact of <jats:italic>U2AF1<\/jats:italic> and <jats:italic>SRSF2<\/jats:italic> mutations. In total, 122 patients with MDS (30%), acute myeloid leukemia (51%), myeloproliferative neoplasms (MPN) (11%), and MDS\/MPN (8%) receiving a HCT from 2003 to 2012 were evaluated for mutations in <jats:italic>U2AF1<\/jats:italic> and <jats:italic>SRSF2<\/jats:italic> by direct sequencing. Median time of follow up was 24 months (range 0.46\u2013110). <jats:italic>SRSF2<\/jats:italic> mutations were detected in 11 (10%) patients and <jats:italic>U2AF1<\/jats:italic> in 3 (3%) patients. There were no significant differences in baseline characteristics between mutated and wild\u2010type (WT) patients. Patients carrying <jats:italic>SRSF2<\/jats:italic> and <jats:italic>U2AF1<\/jats:italic> mutations had similar overall survival (<jats:italic>P<\/jats:italic>\u2009=\u20090.84), relapse mortality (<jats:italic>P<\/jats:italic>\u2009=\u20090.50), and non\u2010relapse mortality (<jats:italic>P<\/jats:italic>\u2009=\u20090.72) compared to WT patients. However, taking into account disease status and cytogenetics in a subset of AML patients, <jats:italic>SRSF2<\/jats:italic> and <jats:italic>U2AF1<\/jats:italic> mutations were associated with worse survival (HR 3.71, <jats:italic>P<\/jats:italic>\u2009=\u20090.035). Am. J. Hematol. 91:406\u2013409, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24306","type":"journal-article","created":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T00:36:40Z","timestamp":1453509400000},"page":"406-409","source":"Crossref","is-referenced-by-count":20,"title":["Impact of allogeneic hematopoietic cell transplant in patients with myeloid neoplasms carrying spliceosomal mutations"],"prefix":"10.1002","volume":"91","author":[{"given":"Betty Ky","family":"Hamilton","sequence":"first","affiliation":[{"name":"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Visconte","sequence":"additional","affiliation":[{"name":"Department of Translational Hematology and Oncology Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Cleveland Clinic Lerner Research Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Tabarroki","sequence":"additional","affiliation":[{"name":"Department of Translational Hematology and Oncology Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Makishima","sequence":"additional","affiliation":[{"name":"Department of Translational Hematology and Oncology Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edy","family":"Hasrouni","sequence":"additional","affiliation":[{"name":"Department of Translational Hematology and Oncology Cleveland Clinic Taussig Cancer Institute Cleveland 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Marrow Transplant Program, Department of Hematology and Medical Oncology Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hien","family":"Duong Liu","sequence":"additional","affiliation":[{"name":"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Bolwell","sequence":"additional","affiliation":[{"name":"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslaw P.","family":"Maciejewski","sequence":"additional","affiliation":[{"name":"Department of Translational Hematology and Oncology Cleveland Clinic Taussig Cancer Institute Cleveland Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Copelan","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Levine Cancer Institute, Carolinas HealthCare System Charlotte North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon V.","family":"Tiu","sequence":"additional","affiliation":[{"name":"Early Phase Oncology Eli\u2010Lilly and Company Indianapolis 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