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Acquired telomerase reverse transcriptase gene promoter (<jats:italic>TERT<\/jats:italic>p) mutations are among the most frequent somatic non\u2010coding mutations in cancers. In this study, the prevalence of<jats:italic>TERT<\/jats:italic>p mutations in 24 MCL and 21 other lymphoid neoplasias (oLN) was investigated. Eight MCL samples (33%) carried<jats:italic>TERT<\/jats:italic>p mutations, two homozygous and six heterozygous (seven C228T and one C250T), which directly correlated with higher<jats:italic>TERT<\/jats:italic>transcription, mitochondrial DNA copy number, and<jats:italic>IGHV<\/jats:italic>mutational status in MCL neoplastic cells.<jats:italic>TERT<\/jats:italic>p mutations were not found in oLN.<jats:italic>TERT<\/jats:italic>p mutations correlated with more lymphoma proliferation and tumor burden, as suggested by the higher number of lymphoma cells circulating in peripheral blood, and tended to associate with longer MCL telomeres, especially in homozygous mutants, although not statistically significant. Telomere\u2010biology genes were overexpressed in MCL cells in comparison to healthy lymphocytes, but were not influenced by mutation status. The findings described for the first time that acquired<jats:italic>TERT<\/jats:italic>p mutations are common in MCL but not in other lymphoid neoplasms. It was also demonstrated that<jats:italic>TERT<\/jats:italic>p mutations are associated with higher<jats:italic>TERT<\/jats:italic>mRNA expression in MCL cells in vivo and higher tumor burden, suggesting these mutations as a driver event in MCL development and progression. Am. J. Hematol. 91:481\u2013485, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24324","type":"journal-article","created":{"date-parts":[[2016,2,7]],"date-time":"2016-02-07T02:35:20Z","timestamp":1454812520000},"page":"481-485","source":"Crossref","is-referenced-by-count":29,"title":["Acquired<scp><i>TERT<\/i><\/scp>promoter mutations stimulate<scp><i>TERT<\/i><\/scp>transcription in mantle cell lymphoma"],"prefix":"10.1002","volume":"91","author":[{"given":"Julieta","family":"Panero","sequence":"first","affiliation":[{"name":"Laboratorio de Gen\u00e9tica de Neoplasias Linfoides, Instituto de Medicina Experimental CONICET\u2010Academia Nacional de Medicina Buenos Aires C1425AUM Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel M.","family":"Alves\u2010Paiva","sequence":"additional","affiliation":[{"name":"Divis\u00e3o De Hematologia, Departamento de Cl\u00ednica M\u00e9dica Faculdade de Medicina de Ribeir\u00e3o Preto da Universidade 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