{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T19:56:07Z","timestamp":1771617367882,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T00:00:00Z","timestamp":1459728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Central nervous system (CNS) involvement in patients with mature B non\u2010Hodgkin lymphoma, post\u2010transplantation proliferative disorder and acute lymphoblastic leukemia confers a significantly inferior prognosis as compared to patients without CNS disease. Intrathecal (IT) or intraventricular administration of rituximab is an option for this group of patients. We report 25 children with CNS involvement of CD20+ B lymphoid malignancies who received in total 163 IT\/intraventricular rituximab doses. The median number of doses received by each patient was 6, with a median dose of 25 mg. The most common adverse events were Grades 1 and 2 peripheral neuropathies in five patients (20%), allergy in two patients, and headache in two patients. These events were self\u2010limited, occurring in the 48 hours after treatment and resolving within 24 hr. Three patients presented with more severe though transient side effects, one with a Grade III neuropathy and two with seizure. Eighteen patients (72%) of those treated with IT\/intraventricular rituximab, with or without other CNS directed treatment, achieved a CNS remission. This case series suggests that IT\/intraventricular rituximab has therapeutic efficacy and relatively limited toxicity. Prospective trials of IT\/intraventricular rituximab for patients with CNS involvement of CD20\u2009+\u2009B lymphoid malignancies are warranted. Am. J. Hematol. 91:486\u2013491, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24329","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T12:29:55Z","timestamp":1455366595000},"page":"486-491","source":"Crossref","is-referenced-by-count":33,"title":["Safety and efficacy of intrathecal rituximab in children with <scp>B<\/scp> cell lymphoid CD20+ malignancies: An international retrospective study"],"prefix":"10.1002","volume":"91","author":[{"given":"Francesco","family":"Ceppi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Hematology\/Oncology Hospital for Sick Children Ontario Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Weitzman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology\/Oncology Hospital for Sick Children Ontario Toronto Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm","family":"Woessmann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Children's Hospital and Justus\u2010Liebig\u2010University Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Dana\u2010Farber\/Boston Children's Cancer and Blood Disorders Center Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Lassaletta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Reism\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Medical University of Vienna, St. Anna Children's Hospital Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Mellgren","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Institution for Clinical Sciences, Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Uyttebroeck","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010Oncology University Hospitals of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Maia","sequence":"additional","affiliation":[{"name":"Pediatric Service, Portuguese Institute of Oncology Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaker","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Pediatric Oncology, King Abdulaziz Medical City \u2013 National Guard Health Affairs  Jeddah Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Miakova","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Federal Center for Pediatric Hematology, Oncology and Immunology Named by D. 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