{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:32:19Z","timestamp":1792668739128,"version":"4.5.0"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T00:00:00Z","timestamp":1461110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Epstein\u2013Barr virus (EBV)\u2010positive diffuse large B\u2010cell lymphoma (DLBCL) of the elderly is a provisional entity included in the 2008 WHO classification of lymphoid neoplasms. It is a disease typically seen in the elderly and thought to be associated with chronic EBV infection and severe immunosuppression with a component of immunosenescence. Recent research, however, has suggested that EBV\u2010positive DLBCL can be seen in younger, immunocompetent patients.<\/jats:p><jats:p>The diagnosis of EBV\u2010positive DLBCL of the elderly is made through a careful pathological evaluation. The differential diagnosis includes infectious mononucleosis (specifically in younger patients), lymphomatoid granulomatosis, Hodgkin lymphoma, and gray zone lymphoma, among others. Detection of EBV\u2010encoded RNA (EBER) is considered standard for diagnosis; however, a clear cutoff for positivity has not been defined.<\/jats:p><jats:p>The International Prognostic Index (IPI), and the Oyama score can be used for risk\u2010stratification. The Oyama score includes age &gt;70 years and presence of B symptoms. The expression of CD30 is emerging as a potential adverse, and targetable, prognostic factor.<\/jats:p><jats:p>Patients with EBV\u2010positive DLBCL should be staged and managed following similar guidelines than patients with EBV\u2010negative DLBCL. It has been suggested, however, that EBV\u2010positive patients have a worse prognosis than EBV\u2010negative counterparts in the era of chemoimmunotherapy. There is an opportunity to study and develop targeted therapy in the management of patients with EBV\u2010positive DLBCL. Am. J. Hematol. 91:530\u2013537, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24370","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T07:44:22Z","timestamp":1461138262000},"page":"529-537","source":"Crossref","is-referenced-by-count":83,"title":["EBV\u2010positive diffuse large B\u2010cell lymphoma of the elderly: 2016 update on diagnosis, risk\u2010stratification, and management"],"prefix":"10.1002","volume":"91","author":[{"given":"Jorge J.","family":"Castillo","sequence":"first","affiliation":[{"name":"Division of Hematologic Malignancies Dana\u2010Farber Cancer Institute, Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brady E.","family":"Beltran","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapy Hospital Nacional Edgardo Rebagliati Martins Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto N.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Hematopathology the University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken H.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Hematopathology the University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Chavez","sequence":"additional","affiliation":[{"name":"Division of Malignant Hematology, Moffitt Cancer Center &amp; Research Institute, University of South Florida Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo M.","family":"Sotomayor","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology George Washington Cancer Center, George Washington University Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,20]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"243","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Nakamura S","year":"2008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200301000-00003"},{"key":"e_1_2_8_4_1","first-page":"5124","article-title":"Age\u2010related EBV\u2010associated B\u2010cell lymphoproliferative disorders constitute a distinct clinicopathologic group: A study of 96 patients. 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