{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:46:36Z","timestamp":1773773196147,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,24]],"date-time":"2016-04-24T00:00:00Z","timestamp":1461456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Patients with peripheral T cell lymphomas (PTCL) generally have a poor prognosis when treated with conventional chemotherapy. Consolidation with autologous stem cell transplantation (ASCT) has been reported to improve progression\u2010free survival. However, these studies have not compared consolidative ASCT with active observation in patients with PTCL achieving first complete remission (CR1) following induction chemotherapy. We conducted a retrospective analysis of PTCL patients treated at the University of Pennsylvania between 1\/1\/2007 and 12\/31\/2014. Patients with cutaneous T cell lymphoma, concurrent B cell lymphomas, and anaplastic lymphoma kinase\u2010positive anaplastic large cell lymphoma (ALK\u2010positive ALCL) were excluded from the study. We compared progression\u2010free survival for patients who underwent ASCT in CR1 following CHOP\u2010like induction regimens and patients who underwent active observation during CR1. 48 patients met all inclusion and exclusion criteria and underwent either active observation (28 patients) or consolidative ASCT (20 patients) in CR1. The 1\u2010year cumulative incidence of relapse in the observation and ASCT groups was 50% (95% confidence interval [CI]: 30\u201367%) and 46% (95% CI: 23\u201367%), respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.55). Median progression\u2010free survival in the observation and ASCT groups was 15.8 and 12.8\u00a0months, respectively (log rank, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.79). Estimated 3\u2010year progression\u2010free survival in the observation and ASCT groups was 37 and 41%, respectively. In conclusion, for PTCL patients achieving CR1 following CHOP\u2010like induction chemotherapy, ASCT does not appear to improve progression\u2010free survival compared to active observation. This finding should be confirmed in a larger, prospective study. Am. J. Hematol. 91:672\u2013676, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24372","type":"journal-article","created":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T08:18:55Z","timestamp":1458893935000},"page":"672-676","source":"Crossref","is-referenced-by-count":28,"title":["Autologous stem cell transplantation in first complete remission may not extend progression\u2010free survival in patients with peripheral T cell lymphomas"],"prefix":"10.1002","volume":"91","author":[{"given":"Clinton","family":"Yam","sequence":"first","affiliation":[{"name":"Abramson Cancer Center and the Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Landsburg","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center and the Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin T.","family":"Nead","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Lin","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony R.","family":"Mato","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center and the Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Svoboda","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center and the Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison W.","family":"Loren","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center and the Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelle V.","family":"Frey","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center and the Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward A.","family":"Stadtmauer","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center and the Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Porter","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center and the Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Schuster","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center and the Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunita D.","family":"Nasta","sequence":"additional","affiliation":[{"name":"Abramson Cancer Center and the Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.131"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70664-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70002-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190290016926"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-5-364"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a057673"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-004-0020-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819021000039983"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-270785"},{"key":"e_1_2_6_11_1","first-page":"76","article-title":"Prognostic significance of T\u2010cell phenotype in aggressive non\u2010Hodgkin's lymphomas. Groupe d'Etudes des Lymphomes de l'Adulte (GELA)","volume":"92","author":"Gisselbrecht C","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.2719"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.4870"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2153"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.5.1954.bloodjournal8651954"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-134270"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.2345"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.11.3913"},{"key":"e_1_2_6_19_1","unstructured":"National Comprehensive Cancer Network: Non\u2010Hodgkin's Lymphomas: Peripheral T\u2010Cell Lymphomas Version 1 2016"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198212000-00014"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh392"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2094"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2095"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.8.1573"},{"key":"e_1_2_6_27_1","first-page":"943","article-title":"[Clinical outcomes of patients with peripheral T\u2010cell lymphoma (PTCL) treated by EPOCH regimen]","volume":"23","author":"Peng YL","year":"2004","journal-title":"Ai Zheng"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20999"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V71.1.117.117"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357900600814490"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-573089"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu443"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13226"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg459"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404306"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2007.00856.x"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.24372","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.24372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:58:05Z","timestamp":1695502685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.24372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,24]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1002\/ajh.24372"],"URL":"https:\/\/doi.org\/10.1002\/ajh.24372","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,24]]}}}