{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T04:33:18Z","timestamp":1722141198778},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Myeloproliferative neoplasm (MPN)\u2010associated myelofibrosis is a clonal, neoplastic disorder of the hematopoietic stem cells, in which inflammation and immune dysregulation play an important role. Extracellular nicotinamide phosphoribosyltransferase (eNAMPT), also known as visfatin, is a cytokine implicated in a number of inflammatory and neoplastic diseases. Here plasma levels of eNAMPT in patients with MPN\u2010associated myelofibrosis and their effects on disease phenotype and outcomes were examined. The concordance of eNAMPT levels with the marker of general inflammation high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) was also studied. A total of 333 MPN\u2010associated myelofibrosis patients (187 males and 146 females) and 31 age\u2010 and gender\u2010matched normal\u2010weight healthy subjects were enrolled in the study main body. Levels of eNAMPT and hs\u2010CRP were simultaneously assayed in 209 MPN\u2010associated myelofibrosis patients. Twenty\u2010four polycythemia vera or essential thrombocythemia patients were used as controls. eNAMPT was over expressed in MPN\u2010associated myelofibrosis, and eNAMPT expression was correlated with higher white blood cell count, higher hemoglobin, and higher platelet count, suggesting that eNAMPT is an indispensable permissive agent for myeloproliferation of MPN\u2010associated myelofibrosis. The lack of correlation between eNAMPT and hs\u2010CRP revealed that eNAMPT in MPN\u2010associated myelofibrosis does not behave as a canonical inflammatory cytokine. In addition, higher levels of eNAMPT predicted longer time to blast transformation, and protected against progression toward thrombocytopenia and large splenomegaly. In conclusion, in MPN\u2010associated myelofibrosis high levels of eNAMPT mark the myeloproliferative potential and, at variance with a high number of cancers, are protective against disease progression. Am. J. Hematol. 91:709\u2013713, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24388","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T13:39:02Z","timestamp":1460554742000},"page":"709-713","source":"Crossref","is-referenced-by-count":6,"title":["Increased plasma nicotinamide phosphoribosyltransferase is associated with a hyperproliferative phenotype and restrains disease progression in MPN\u2010associated myelofibrosis"],"prefix":"10.1002","volume":"91","author":[{"given":"Vittorio","family":"Rosti","sequence":"first","affiliation":[{"name":"Center for the Study of Myelofibrosis. Biotechnology Research Area, IRCCS Policlinico S. Matteo Foundation Pavia 27100 Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Campanelli","sequence":"additional","affiliation":[{"name":"Center for the Study of Myelofibrosis. Biotechnology Research Area, IRCCS Policlinico S. 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