{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:41:40Z","timestamp":1789040500090,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Genentech Inc., South San Francisco, CA\/F"},{"name":"Hoffmann-La Roche Ltd, Basel, Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>We aimed to comprehensively study sex differences in disease and patients' characteristics, treatment and outcomes in patients with follicular lymphoma (FL) in the United States (USA) utilizing the National LymphoCare Study registry (2004\u20132014). Among evaluable males (<jats:italic>n<\/jats:italic>\u2009=\u20091277) and females (<jats:italic>n<\/jats:italic>\u2009=\u20091375) with FL, females less commonly received anthracyclines and were more likely to receive rituximab monotherapy. Overall response rates were comparable between sex groups. With a median follow\u2010up of 8.1 years, male sex emerged as an adverse factor for PFS (HR, 0.84, 95% CI, 0.72\u20130.97). Lymphoma\u2010related mortality (HR, 0.46; 0.23\u20130.93) and overall survival (HR, 0.63; 0.41\u20130.97) favored females aged \u226460 years. There are subtle differences in outcomes between male and female FL patients diagnosed and treated in the contemporary era. These data represent the largest prospective analysis of FL patients in the USA based on sex and can aid design of clinical trials for this disease. Am. J. Hematol. 91:770\u2013775, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24401","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T09:19:29Z","timestamp":1462007969000},"page":"770-775","source":"Crossref","is-referenced-by-count":21,"title":["Disease, treatment, and outcome differences between men and women with follicular lymphoma in the United States"],"prefix":"10.1002","volume":"91","author":[{"given":"Chadi","family":"Nabhan","sequence":"first","affiliation":[{"name":"Section of Hematology and Oncology Department of Medicine the University of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Biometrics, RTI Health Solutions  North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bann\u2010Mo","family":"Day","sequence":"additional","affiliation":[{"name":"Medical Affairs, Genentech, Inc  California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Dawson","sequence":"additional","affiliation":[{"name":"Medical Affairs, Genentech, Inc  California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Zelenetz","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Friedberg","sequence":"additional","affiliation":[{"name":"James P Wilmot Cancer Center the University of Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Health Sciences Research Mayo Clinic New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Medicine the University of Iowa  Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Flowers","sequence":"additional","affiliation":[{"name":"Winship Cancer Institute Emory University  Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13399"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27513"},{"key":"e_1_2_7_5_1","first-page":"783","article-title":"Prognosis of follicular lymphoma: A predictive model based on a retrospective analysis of 987 cases. 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