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The establishment of CMV\u2010specific immunity controls viral reactivation and leads to the accumulation of very large numbers of virus\u2010specific T cells which come to dominate the immune repertoire. There is concern that this may reduce the immune response to heterologous infections and HCMV infection has been associated with reduced survival in elderly people. Patients with chronic lymphocytic leukemia (B\u2010CLL) suffer from a state of immune suppression but have a paradoxical increase in the magnitude of the CMV\u2010specific T cell and humoral immune response. As such, there is now considerable interest in how CMV infection impacts on the clinical outcome of patients with B\u2010CLL. Utilizing a large prospective cohort of patients with B\u2010CLL (<jats:italic>n<\/jats:italic>\u2009=\u2009347) we evaluated the relationship between HCMV seropositivity and patient outcome. HCMV seropositive patients had significantly worse overall survival than HCMV negative patients in univariate analysis (HR\u2009=\u20092.28, 95% CI: 1.34\u20133.88; <jats:italic>P<\/jats:italic>\u2009=\u20090.002). However, CMV seropositive patients were 4 years older than seronegative donors and this survival difference was lost in multivariate modeling adjusted for age and other validated prognostic markers (<jats:italic>P<\/jats:italic>\u2009=\u20090.34). No significant difference was found in multivariate modeling between HCMV positive and negative patients in relation to the time to first treatment (HR\u2009=\u20091.12, 95% CI: 0.68\u20131.84; <jats:italic>P<\/jats:italic>\u2009=\u20090.65). These findings in a second independent cohort of 236 B\u2010CLL patients were validated. In conclusion no evidence that HCMV impacts on the clinical outcome of patients with B\u2010CLL was found. Am. J. Hematol. 91:776\u2013781, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24403","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T09:19:29Z","timestamp":1462007969000},"page":"776-781","source":"Crossref","is-referenced-by-count":13,"title":["Cytomegalovirus infection does not impact on survival or time to first treatment in patients with chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"91","author":[{"given":"Helen Marie","family":"Parry","sequence":"first","affiliation":[{"name":"Institute of Immunology and Immunotherapy University of Birmingham Birmingham B15 2TT United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Damery","sequence":"additional","affiliation":[{"name":"Institute of Applied Health Research University of Birmingham Birmingham B15 2TT United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Hudson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine &amp; Health Sciences University of Nottingham Leicestershire LE12 5RD United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Pachnio","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy University of Birmingham Birmingham B15 2TT United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jusnara","family":"Begum","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy University of Birmingham Birmingham B15 2TT United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Slager","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Fegan","sequence":"additional","affiliation":[{"name":"Division of Cancer &amp; Genetics Heath Park Cardiff CF14 4XN United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Man","sequence":"additional","affiliation":[{"name":"Division of Cancer &amp; Genetics Heath Park Cardiff CF14 4XN United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Pepper","sequence":"additional","affiliation":[{"name":"Division of Cancer &amp; Genetics Heath Park Cardiff CF14 4XN United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tait D.","family":"Shanafelt","sequence":"additional","affiliation":[{"name":"Department of Medicine Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Pratt","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy University of Birmingham Birmingham B15 2TT United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A. 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