{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:08:53Z","timestamp":1791950933726,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Several studies reported improved outcomes of adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) treated with pediatric\u2010based ALL regimens. This prompted the prospective investigation of a pediatric Augmented Berlin\u2013Frankfurt\u2013M\u00fcnster (ABFM) regimen, and its comparison with hyper\u2010fractionated cyclophosphamide, vincristine, Adriamycin, and dexamethasone (hyper\u2010CVAD) in AYA patients. One hundred and six AYA patients (median age 22 years) with Philadelphia chromosome\u2010 (Ph) negative ALL received ABFM from October 2006 through March 2014. Their outcome was compared to 102 AYA patients (median age 27 years), treated with hyper\u2010CVAD at our institution. The complete remission (CR) rate was 93% with ABFM and 98% with hyper\u2010CVAD. The 5\u2010year complete remission duration (CRD) were 53 and 55%, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.98). The 5\u2010year overall survival (OS) rates were 60 and 60%, respectively. The MRD status on Day 29 and Day 84 of therapy was predictive of long\u2010term outcomes on both ABFM and hyper\u2010CVAD. Severe regimen toxicities with ABFM included hepatotoxicity in 41%, pancreatitis in 11%, osteonecrosis in 9%, and thrombosis in 19%. Myelosuppression\u2010associated complications were most significant with hyper\u2010CVAD. In summary, ABFM and hyper\u2010CVAD resulted in similar efficacy outcomes, but were associated with different toxicity profiles, asparaginase\u2010related with ABFM and myelosuppression\u2010related with hyper\u2010CVAD. Am. J. Hematol. 91:819\u2013823, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24419","type":"journal-article","created":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T08:32:55Z","timestamp":1463214775000},"page":"819-823","source":"Crossref","is-referenced-by-count":122,"title":["Final results of a single institution experience with a pediatric\u2010based regimen, the augmented Berlin\u2013Frankfurt\u2013M\u00fcnster, in adolescents and young adults with acute lymphoblastic leukemia, and comparison to the hyper\u2010CVAD regimen"],"prefix":"10.1002","volume":"91","author":[{"given":"Michael E.","family":"Rytting","sequence":"first","affiliation":[{"name":"Pediatrics\u2010Patient Care the University of Texas MD Anderson Cancer Center, Texas"},{"name":"Department of Leukemia the University of Texas MD Anderson Cancer Center, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias 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