{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:25Z","timestamp":1786976845044,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T00:00:00Z","timestamp":1470268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Lundbeck and Novo Nordisk Foundation Programme for Clinical Research Infrastructure"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>In patients with systemic mastocytosis (SM), several aspects of morbidity remain poorly understood. We assessed the risk of solid cancers, cardiovascular disease, anaphylaxis, osteoporosis, and fractures in SM patients. Using Danish medical registries, we conducted a nationwide population\u2010based cohort study including 687 adult (\u226515 years) SM patients diagnosed during 1997\u20132012. A comparison cohort of 68,700 subjects from the general Danish population who were alive and without SM at the given SM subject's diagnosis were age\u2010 and gender\u2010matched. Outcomes were a new diagnosis of solid cancer, venous thromboembolism (VTE), myocardial infarction (MI), stroke, anaphylaxis, osteoporosis, or fracture. For solid cancers the hazard ratio (HR) was 2.4 (95% confidence interval [CI] 1.9\u20132.8) with a 10\u2010year absolute risk (AR) in the SM\u2010cohort of 12.6% (95% CI 9.4\u201316.3). Specifically, we found a HR of 7.5 (95% CI 4.4\u201313.0) for melanoma and a HR of 2.5 (95% CI 1.7\u20133.5) for non\u2010melanoma skin cancers (NMSCs). For VTE we found a HR of 1.9 (95% CI 1.2\u20133.0), with a 10\u2010year AR of 3.9% (95% CI 2.3\u20136.1); for MI a nonsignificant increased HR of 1.4 (95% CI 0.9\u20132.3), with a 10\u2010year AR of 1.8% (95% CI 0.9\u20133.2); and for stroke a HR of 1.6 (95% CI 1.1\u20132.3) with a 10\u2010year AR of 4.6% (95% CI 2.8\u20136.9). The HR for anaphylaxis was 7.2 (95% CI 5.3\u20139.9), and the 10\u2010year AR was 3.1% (95% CI 1.9\u20134.9). For osteoporosis the HR was 3.6 (95% CI 2.7\u20134.6) with a 10\u2010year AR of 7.2% (95% CI 5.2\u20139.8). For fractures the HR was 1.2 (95% CI 0.9\u20131.6) and the 10\u2010year AR was 5.9% (95% CI 3.9\u20138.4). SM patients are at increased risk of solid cancers \u2013 especially melanoma and NMSC\u2014and cardiovascular disease. The risk of anaphylaxis and osteoporosis is clearly increased in SM, though absolute risk was low in this population\u2010based study. The fracture\u2010risk was only slightly increased. Am. J. Hematol. 91:1069\u20131075, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24490","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T19:03:09Z","timestamp":1468868589000},"page":"1069-1075","source":"Crossref","is-referenced-by-count":74,"title":["Risk of solid cancer, cardiovascular disease, anaphylaxis, osteoporosis and fractures in patients with systemic mastocytosis: A nationwide population\u2010based study"],"prefix":"10.1002","volume":"91","author":[{"given":"Sigurd","family":"Broesby\u2010Olsen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital Odense Denmark"},{"name":"Mastocytosis Centre, Odense University Hospital (MastOUH) Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f3ra K\u00f6rmendin\u00e9","family":"Farkas","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University 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Gotthard","family":"Mortz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital Odense Denmark"},{"name":"Mastocytosis Centre, Odense University Hospital (MastOUH) Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Kielsgaard","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Mastocytosis Centre, Odense University Hospital (MastOUH) Odense Denmark"},{"name":"Department of Pathology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Bindslev\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital Odense Denmark"},{"name":"Mastocytosis Centre, Odense University Hospital (MastOUH) Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik 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