{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:03:00Z","timestamp":1792508580137,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,3]],"date-time":"2016-09-03T00:00:00Z","timestamp":1472860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 CA9727"],"award-info":[{"award-number":["P50 CA9727"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Recent advances in follicular lymphoma (FL) have resulted in prolongation of overall survival (OS). Here we assessed if early events as defined by event\u2010free survival (EFS) at 12 and 24 months from diagnosis (EFS12\/EFS24) can inform subsequent OS in FL. 920 newly diagnosed grade 1\u20103A FL patients enrolled on the University of Iowa\/Mayo Clinic Lymphoma SPORE Molecular Epidemiology Resource (MER) from 2002\u20102012 were initially evaluated. EFS was defined as time from diagnosis to progression, relapse, re\u2010treatment, or death due to any cause. OS was compared to age\u2010and\u2010sex\u2010matched survival in the general US population using standardized mortality ratios (SMR) and 95% confidence intervals (CI). We used a cohort of 412 FL patients from two Lyon, France hospital registries for independent replication. Patients who failed to achieve EFS12 had poor subsequent OS (MER SMR\u2009=\u20093.72, 95%CI: 2.78\u20104.88; Lyon SMR\u2009=\u20098.74, 95%CI: 5.41\u201013.36). Conversely, patients achieving EFS12 had no added mortality beyond the background population (MER SMR\u2009=\u20090.73, 95%CI: 0.56\u20100.94, Lyon SMR\u2009=\u20091.02, 95%CI: 0.58\u20101.65). Patients with early events after immunochemotherapy had especially poor outcomes (EFS12 failure: MER SMR\u2009=\u200917.63, 95%CI:11.97\u201025.02, Lyon SMR\u2009=\u200919.10, 95%CI:9.86\u201033.36; EFS24 failure: MER SMR\u2009=\u200913.02, 95%CI:9.31\u201017.74, Lyon SMR\u2009=\u20097.22, 95%CI:4.13\u201011.74). In a combined dataset of all patients from both cohorts, baseline FLIPI was no longer informative in EFS12 achievers. Reassessment of patient status at 12 months from diagnosis in follicular lymphoma patients, or at 24 months in patients treated with immunochemotherapy, is a strong predictor of subsequent overall survival in FL. Early event status provides a simple, clinically relevant endpoint for studies assessing outcome in FL. Am. J. Hematol. 91:1096\u20131101, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24492","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T01:52:43Z","timestamp":1469670763000},"page":"1096-1101","source":"Crossref","is-referenced-by-count":216,"title":["Early event status informs subsequent outcome in newly diagnosed follicular lymphoma"],"prefix":"10.1002","volume":"91","author":[{"given":"Matthew J.","family":"Maurer","sequence":"first","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Bachy","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospices Civils De Lyon, Centre Hospitalier Lyon\u2010Sud and Universit\u00e9 Claude Bernard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Ghesqui\u00e8res","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospices Civils De Lyon, Centre Hospitalier Lyon\u2010Sud and Universit\u00e9 Claude Bernard Lyon France"},{"name":"Department of Medical Oncology Centre L\u00e9on B\u00e9rard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Ansell","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz S.","family":"Nowakowski","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Inwards","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristine","family":"Allmer","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Chassagne\u2010Cl\u00e9ment","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre L\u00e9on B\u00e9rard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Nicolas\u2010Virelizier","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Centre L\u00e9on B\u00e9rard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Sebban","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Centre L\u00e9on B\u00e9rard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Lebras","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospices Civils De Lyon, Centre Hospitalier Lyon\u2010Sud and Universit\u00e9 Claude Bernard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementine","family":"Sarkozy","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospices Civils De Lyon, Centre Hospitalier Lyon\u2010Sud and Universit\u00e9 Claude Bernard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Macon","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei I.","family":"Syrbu","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa Iowa City IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Traverse\u2010Glehan","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospices Civils De Lyon, Centre Hospitalier Lyon\u2010Sud and Universit\u00e9 Claude Bernard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Coiffier","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospices Civils De Lyon, Centre Hospitalier Lyon\u2010Sud and Universit\u00e9 Claude Bernard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Slager","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology and Blood and Marrow Transplantation, University of Iowa Iowa City IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Witzig","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Habermann","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospices Civils De Lyon, Centre Hospitalier Lyon\u2010Sud and Universit\u00e9 Claude Bernard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Salles","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospices Civils De Lyon, Centre Hospitalier Lyon\u2010Sud and Universit\u00e9 Claude Bernard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology and Blood and Marrow Transplantation, University of Iowa Iowa City IA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2508"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.0283"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.3990"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12570"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.1561"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3175"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-153189"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0016"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.4618"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.8052"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.3696"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.1674"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-491514"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds429"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4434"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(14)70008-0"},{"key":"e_1_2_7_18_1","article-title":"Evaluation of complete response rate at 30 months (CR30) as a surrogate for progression\u2010free survival (PFS) in first\u2010line follicular lymphoma (FL) studies: Results from the prospectively specified Follicular Lymphoma Analysis of Surrogacy Hypothesis (FLASH) analysis with individual patient data (IPD) of 3,837 patients (pts)","volume":"33","author":"Sargent DanielJ","year":"2015","journal-title":"J Clin Oncol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.7534"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.5866"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4245"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.6674"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2130"},{"key":"e_1_2_7_24_1","unstructured":"TherneauTM.A Package for Survival Analysis in S. version 2.38 http:\/\/CRAN.R-project.org\/package=survival. (ed version 2.38);2015."},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","unstructured":"JaisJ\u2010P VaretH.Survexp.fr: Relative survival AER and SMR based on French death rates (R package version 1.0).http:\/\/cran.r-project.org\/web\/packages\/survexp.fr\/index.html2013.","DOI":"10.32614\/CRAN.package.survexp.fr"},{"key":"e_1_2_7_26_1","unstructured":"TherneauT SicksJ BergstralhEJ. O.Technical Report Series No. 52 Expected Survival Based on Hazard Rates. Department of Health Sciences Research Mayo Clinic Rochester Minnesota March1994."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)93073-A"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1983.10477915"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.24492","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.24492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T06:43:58Z","timestamp":1749019438000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.24492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,3]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/ajh.24492"],"URL":"https:\/\/doi.org\/10.1002\/ajh.24492","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,3]]}}}