{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:09:26Z","timestamp":1776449366355,"version":"3.51.2"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Recent literature has demonstrated concern over the risk of <jats:italic>Pneumocystis jirovecii<\/jats:italic> pneumonia (PJP) when administering rituximab with combination chemotherapy such as in R\u2010CHOP; however, the exact risk and potential need for prophylaxis is unknown. We sought to determine the incidence of PJP infection following R\u2010CHOP administration in patients with B\u2010cell lymphoma. Consecutive patients diagnosed with B\u2010cell lymphoma receiving R\u2010CHOP were evaluated from chemotherapy initiation until 180 days after the last administration. The primary outcome was cumulative incidence of PJP infection. Secondary endpoints included the association of rituximab, prednisone and subsequent chemotherapy with PJP infection risk. A total of 689 patients (53% male, median age 66 years) were included. Seventy\u2010three percent of patients completed at least 6 cycles of R\u2010CHOP treatment. Median rituximab and prednisone cumulative doses were 3950 mg and 5325 mg, respectively. Median daily prednisone dose through end of treatment was 45 mg (range 7.6 mg to 119 mg). The cumulative incidence of PJP was 1.51% (95% CI 0.57\u20132.43, at maximum follow\u2010up of 330 days), below 3.5%, the conventional threshold for prophylaxis. Univariate analysis did not detect a statistically significant association between PJP and rituximab, steroids, or receipt of additional chemotherapy in this patient population. Our results demonstrate a low occurrence of <jats:italic>Pneumocystis<\/jats:italic> pneumonia during R\u2010CHOP treatment of B\u2010cell lymphoma and argue against universal anti\u2010<jats:italic>Pneumocystis<\/jats:italic> prophylaxis in this setting. Further investigations should focus on targeted anti\u2010<jats:italic>Pneumocystis<\/jats:italic> prophylaxis for patients presenting with high\u2010risk baseline characteristics or when receiving rituximab\u2010inclusive intensive combination chemotherapy regimens as treatment for other aggressive lymphoma subtypes. Am. J. Hematol. 91:1113\u20131117, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24499","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T12:24:30Z","timestamp":1471868670000},"page":"1113-1117","source":"Crossref","is-referenced-by-count":28,"title":["Low incidence of pneumocystis pneumonia utilizing PCR\u2010based diagnosis in patients with B\u2010cell lymphoma receiving rituximab\u2010containing combination chemotherapy"],"prefix":"10.1002","volume":"91","author":[{"given":"Jason N.","family":"Barreto","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren L.","family":"Ice","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Spectrum Health Grand Rapids Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine, Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pritish K.","family":"Tosh","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine, Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R.","family":"Osmon","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine, Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross A.","family":"Dierkhising","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew F.","family":"Plevak","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew H.","family":"Limper","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Internal Medicine, Mayo Clinic Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1001\/archinte.1995.00430110015002","article-title":"Pneumocystis carinii pneumonia without acquired immunodeficiency syndrome. 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