{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:18:47Z","timestamp":1788196727624,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T00:00:00Z","timestamp":1478908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Although infectious complications represent a relevant cause of morbidity and mortality in patients with myelofibrosis (MF), little is known about their incidence, outcome and risk factors. We retrospectively evaluated a cohort of 507 MF patients, diagnosed between 1980 and 2014 in five Italian hematology centers, to define the epidemiology of infections and describe the impact of ruxolitinib (RUX) treatment. Overall, 112 patients (22%) experienced 160 infectious events (grade 3\u20134, 45%) for an incidence rate of 3.9% per patient\u2010year. Infections were mainly bacterial (78%) and involving the respiratory tract (52% of cases). Also, viral (11%) and fungal infections (2%) were recorded. Overall, infections were fatal in 9% of the cases. Among baseline features, high\/intermediate\u20102 IPSS category (HR 1.8, 95%CI:1.2\u20132.7; <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and spleen length \u226510 cm below left costal margin (HR 1.6, 95%CI:1.1\u20132.5; <jats:italic>P<\/jats:italic>\u2009=\u20090.04) were associated with higher infectious risk in multivariate analysis. Overall, the rate of infections was higher in the cohort of 128 RUX\u2010treated patients (44% vs. 20%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In conclusion, IPSS\u2010category and splenomegaly, emerged as the main risk factors for infections in MF. RUX\u2010treated patients experienced significantly more infection episodes; however, future prospective studies are needed to isolate the confounding contribution of other risk factors such as disease stage. Am. J. Hematol. 92:37\u201341, 2017. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajh.24572","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T15:37:06Z","timestamp":1476286626000},"page":"37-41","source":"Crossref","is-referenced-by-count":84,"title":["Risk factors for infections in myelofibrosis: role of disease status and treatment. A multicenter study of 507 patients"],"prefix":"10.1002","volume":"92","author":[{"given":"Nicola","family":"Polverelli","sequence":"first","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine (DIMES) Institute of Hematology and Clinical Oncology \u201cL. and A. 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Orsola\u2010Malpighi Hospital, University of Bologna Bologna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Riminucci","sequence":"additional","affiliation":[{"name":"Haematopathology Unit, Cellular Biotechnologies and Hematology University Sapienza Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Godio","sequence":"additional","affiliation":[{"name":"Anatomia Patologica Generale e Oncogenetica Molecolare Citt\u00e0 della Salute e della Scienza Hospital and University Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Catani","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine (DIMES) Institute of Hematology and Clinical Oncology \u201cL. and A. Ser\u00e0gnoli\u201d, Sant'Orsola\u2010Malpighi University Hospital Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Nicolosi","sequence":"additional","affiliation":[{"name":"Hematology Citt\u00e0 della Salute e della Scienza Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Perricone","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine (DIMES) Institute of Hematology and Clinical Oncology \u201cL. and A. Ser\u00e0gnoli\u201d, Sant'Orsola\u2010Malpighi University Hospital Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Sollazzo","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine (DIMES) Institute of Hematology and Clinical Oncology \u201cL. and A. Ser\u00e0gnoli\u201d, Sant'Orsola\u2010Malpighi University Hospital Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioia","family":"Colafigli","sequence":"additional","affiliation":[{"name":"Cellular Biotechnologies and Hematology University Sapienza Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Campana","sequence":"additional","affiliation":[{"name":"Hematology Citt\u00e0 della Salute e della Scienza Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Merli","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Ospedaliera Arcispedale Santa Maria Nuova Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Vitolo","sequence":"additional","affiliation":[{"name":"Hematology Citt\u00e0 della Salute e della Scienza Hospital Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Alimena","sequence":"additional","affiliation":[{"name":"Cellular Biotechnologies and Hematology University Sapienza Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine (DIMES) Institute of Hematology and Clinical Oncology \u201cL. and A. 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