{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:20:16Z","timestamp":1789881616344,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Splanchnic vein thrombosis (SVT) is one of the vascular complications of myeloproliferative neoplasms (MPN). We designed a phase 2 clinical trial to evaluate safety and efficacy of ruxolitinib in reducing splenomegaly and improving disease\u2010related symptoms in patients with MPN\u2010associated SVT. Patients diagnosed with myelofibrosis (12 cases), polycythemia vera (5 cases) and essential thrombocythemia (4 cases) received ruxolitinib for 24 weeks in the core study period. Spleen volume was assessed by magnetic resonance imaging (MRI) and splanchnic vein circulation by echo\u2010Doppler analysis. Nineteen patients carried <jats:italic>JAK2<\/jats:italic>V617F, one had <jats:italic>MPL<\/jats:italic>W515L, and one <jats:italic>CALR<\/jats:italic>L367fs*46 mutation. Eighteen patients had spleno\u2010portal\u2010mesenteric thrombosis, two had Budd\u2013Chiari syndrome, and one had both sites involved; 16 patients had esophageal varices. Ruxolitinib was well tolerated with hematological toxicities consistent with those of patients without SVT and no hemorrhagic adverse events were recorded. After 24 weeks of treatment, spleen volume reduction \u226535% by MRI was achieved by 6\/21 (29%) patients, and a \u226550% spleen length reduction by palpation at any time up to week 24 was obtained by 13\/21 (62%) patients. At week 72, 8 of the 13 (62%) patients maintained the spleen response by palpation. No significant effect of treatment on esophageal varices or in splanchnic circulation was observed. MPN\u2010related symptoms, evaluated by MPN\u2010symptom assessment form (SAF) TSS questionnaire, improved significantly during the first 4 weeks and remained stable up to week 24. In conclusion, this trial shows that ruxolitinib is safe in patients with MPN\u2010associated SVT, and effective in reducing spleen size and disease\u2010related symptoms.<\/jats:p>","DOI":"10.1002\/ajh.24614","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T23:39:04Z","timestamp":1479944344000},"page":"187-195","source":"Crossref","is-referenced-by-count":49,"title":["Safety and efficacy of ruxolitinib in splanchnic vein thrombosis associated with myeloproliferative neoplasms"],"prefix":"10.1002","volume":"92","author":[{"given":"Lisa","family":"Pieri","sequence":"first","affiliation":[{"name":"CRIMM\u2010Centro Ricerca e Innovazione per le Malattie Mieloproliferative, Azienda Ospedaliera\u2010Universitaria Careggi Florence Italy"},{"name":"DenoThe Excellence Center Florence Italy"},{"name":"Department of Experimental and Clinical Medicine University of Florence Florence 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