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Recently, the PFA\u2010100 has been \u201cupgraded\u201d to the PFA\u2010200, which has transformed the user interface and electronic management, but retained the fundamental mechanics, and essentially provides the same results. The PFA\u2010100\/200 has conceivable clinical utility to screen for von Willebrand Disease (VWD) and platelet disorders, and in monitoring desmopressin (DDAVP) therapy in both, and possibly anti\u2010platelet therapy. Its great strengths are its usage simplicity and sensitivity to conditions affecting primary hemostasis. However, as a \u201cglobal\u201d test, its limitation is that closure time (CT) test results are neither predictive of, nor specific for, any individual disorder. However, utilized properly, the PFA\u2010100\/200 reflects a valuable addition to hemostasis laboratories involved in identification or therapeutic\u2010monitoring of disorders of primary hemostasis.<\/jats:p>","DOI":"10.1002\/ajh.24620","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T12:27:21Z","timestamp":1481286441000},"page":"398-404","source":"Crossref","is-referenced-by-count":93,"title":["Clinical utility of closure times using the platelet function analyzer\u2010100\/200"],"prefix":"10.1002","volume":"92","author":[{"given":"Emmanuel J.","family":"Favaloro","sequence":"first","affiliation":[{"name":"Department of Haematology Institute of Clinical Pathology and Medical Research (ICPMR), Sydney Centres for Thrombosis and Haemostasis, NSW Health Pathology, Westmead Hospital NSW 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