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Using a machine\u2010learning algorithm we have previously developed the AL\u2010 European Society for Blood and Marrow Transplantation (EBMT) score for prediction of mortality following transplantation. We report here the first external validation of the AL\u2010EBMT score in a cohort of AL patients from the Italian national transplantation network. A total of 1848 patients transplanted between the years 2000\u20102014 were analyzed. The median age was 45.9. Indications for HSCT were Acute Myeloid Leukemia (68.1%) and Acute Lymphoblastic Leukemia (31.9%). The majority of patients were in first complete remission (60.4%), and received myeloablative conditioning (81.3%). Median follow\u2010up was 2 years. The score was well\u2010calibrated for prediction of day 100 mortality and 2\u2010year overall survival (OS), leukemia free survival (LFS), and nonrelapse related mortality, with corresponding area under the receiver\u2010operator curves of 0.698, 0.651, 0.653, and 0.651, respectively. Increasing score intervals were associated with a decreasing probability of 2\u2010year OS and LFS. The highest scoring group was associated with a hazard ratio of 3.16, 2.8, and 2.27 for 2\u2010year OS, LFS, and NRM, respectively. In conclusion, the AL\u2010EBMT score identified three distinct risk groups and was predictive of OS. It is a valid tool for stratifying the risk of acute leukemia patients undergoing allogeneic HSCT.<\/jats:p>","DOI":"10.1002\/ajh.24677","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T08:43:20Z","timestamp":1486629800000},"page":"429-434","source":"Crossref","is-referenced-by-count":33,"title":["Validation of the acute leukemia\u2010EBMT score for prediction of mortality following allogeneic stem cell transplantation in a multi\u2010center GITMO cohort"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-8032","authenticated-orcid":false,"given":"Roni","family":"Shouval","sequence":"first","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Division Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Dr. Pinchas Bornstein Talpiot Medical Leadership Program, Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University  Israel"},{"name":"Bar\u2010Ilan University Ramat Gan Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Bonifazi","sequence":"additional","affiliation":[{"name":"S. Orsola\u2010Malpighi University Hospital, University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Fein","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation Division Chaim Sheba Medical Center Tel\u2010Hashomer Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University  Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Boschini","sequence":"additional","affiliation":[{"name":"Hematology and BMT Unit Ospedale Papa Giovanni XXIII Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Oldani","sequence":"additional","affiliation":[{"name":"Hematology and BMT Unit Ospedale Papa Giovanni XXIII Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"Acute Leukemia Working Party\u2010Paris Office, Hospital Saint\u2010Antoine, EBMT Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Raimondi","sequence":"additional","affiliation":[{"name":"Hematology and BMT Unit Ospedale San Bortolo Vicenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Sacchi","sequence":"additional","affiliation":[{"name":"Italian Bone Marrow Donor Registry E.O. 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