{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T12:49:15Z","timestamp":1770554955924,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>T\u2010cell prolymphocytic leukemia (T\u2010PLL) is an aggressive mature T\u2010cell neoplasm. The most common cytogenetic abnormality associated with T\u2010PLL is inv(14)(q11.2q32) involving <jats:italic>TCL1<\/jats:italic>, but other abnormalities also have been reported. In this study, we correlated cytogenetic abnormalities with clinical outcome in 97 T\u2010PLL patients, including 66 men and 31 women with a median age of 63 years (range, 34\u201081). Twenty\u2010seven patients had a normal karyotype (NK), one had two chromosomal aberrations, and 69 had a complex karyotype (CK). Patients with a CK had poorer overall survival (OS) than patients with a NK (<jats:italic>P<\/jats:italic>\u2009=\u2009.0016). In the CK group, the most common aberrations involved 14q (n\u2009=\u200945) and 8q (n\u2009=\u200938). Additional deletions of chromosomes 17p, 11q, 6q, 12p, 13q were observed frequently. No individual cytogenetic abnormality impacted OS. Patients with \u22655 aberrations had an OS of 11 months versus 22 months in patients with &lt;5 aberrations (<jats:italic>P<\/jats:italic>\u2009=\u20090.0132). Fluorescence <jats:italic>in situ<\/jats:italic> hybridization for <jats:italic>TCL1<\/jats:italic> successfully performed in 27 cases showed rearrangement in 8\/10 (80%) NK versus 16\/17 (94%) CK cases. OS of patients with <jats:italic>TCL1<\/jats:italic> rearrangement and\/or 14q aberrations was not significantly different from patients without <jats:italic>TCL1<\/jats:italic> rearrangement and 14q aberrations (<jats:italic>P<\/jats:italic>\u2009=\u2009.3467). Patients with refractory disease showed worse OS in both the NK and CK groups (<jats:italic>P<\/jats:italic>\u2009=\u2009.0014 and <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001, respectively), compared with patients who achieved remission but then relapsed. Stem cell transplantation did not appear to improve OS regardless of karyotype complexity. In conclusion, patients with T\u2010PLL often have a CK which is a poor prognostic factor, particularly in patients with \u22655 cytogenetic aberrations.<\/jats:p>","DOI":"10.1002\/ajh.24679","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T08:43:21Z","timestamp":1487061801000},"page":"441-447","source":"Crossref","is-referenced-by-count":35,"title":["Prognostic significance of cytogenetic abnormalities in T\u2010cell prolymphocytic leukemia"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-6729","authenticated-orcid":false,"given":"Zhihong","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianghua","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"},{"name":"Department of Oncology Jiangsu Province Hospital of Traditional Chinese Medicine Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenya","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7333-7478","authenticated-orcid":false,"given":"Tsieh","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres E.","family":"Quesada","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa A.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)93135-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.02.034"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb05023.x"},{"key":"e_1_2_7_5_1","first-page":"270","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Catovsky D","year":"2008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1182\/blood.V86.3.1163.1163","article-title":"True T\u2010cell chronic lymphocytic leukemia: a morphologic and immunophenotypic study of 25 cases","volume":"86","author":"Hoyer JD","year":"1995","journal-title":"Blood."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21405"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/93P42RNG5XBG3KBE"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1182\/blood.V87.8.3520.bloodjournal8783520","article-title":"Similarities between T\u2010cell chronic lymphocytic leukemia and the small\u2010cell variant of T\u2010prolymphocytic leukemia","volume":"87","author":"Matutes E","year":"1996","journal-title":"Blood."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12560"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90228-M"},{"key":"e_1_2_7_12_1","first-page":"27","article-title":"Cytogenetic studies on prolymphocytic leukemia. 1. B\u2010cell prolymphocytic leukemia","volume":"1","author":"Brito\u2010Babapulle V","year":"1987","journal-title":"Hematol Pathol."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(97)00410-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb04829.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.26.12530"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-101519"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204596"},{"key":"e_1_2_7_18_1","first-page":"2475","article-title":"MTCP\u20101: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha\/delta locus in mature T cell proliferations","volume":"8","author":"Stern MH","year":"1993","journal-title":"Oncogene."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1672"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02174.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-4608(03)00161-4"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.01.015"},{"key":"e_1_2_7_23_1","first-page":"2293","article-title":"Ataxia\u2010telangiectasia and T\u2010cell leukemias: no evidence for somatic ATM mutation in sporadic T\u2010ALL or for hypermethylation of the ATM\u2010NPAT\/E14 bidirectional promoter in T\u2010PLL","volume":"58","author":"Luo L","year":"1998","journal-title":"Cancer Res."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.10.3920.3920_3920_3926"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.001347"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23751"},{"key":"e_1_2_7_27_1","article-title":"An international system for human cytogenetic normenclature (ISCN 2013), recommendations of the international standing commitee on human cytogenetic normenclature","author":"Shaffer LGMJSM.","year":"2013","journal-title":"Karger."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2015.1.361"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22141"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13952"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-559542"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22313"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.24679","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.24679","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.24679","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.24679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T19:09:43Z","timestamp":1694718583000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.24679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,27]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/ajh.24679"],"URL":"https:\/\/doi.org\/10.1002\/ajh.24679","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,27]]}}}