{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:02:39Z","timestamp":1792782159221,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"SIRIC Lyric","award":["INCa-DGOS-4664"],"award-info":[{"award-number":["INCa-DGOS-4664"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>BCL2<\/jats:italic>\n                    mutations have been suggested to confer an adverse prognosis to follicular lymphoma (FL) patients, but their prognostic value has not been assessed in patients treated with a rituximab\u2010containing regimen. Here we evaluated the prognostic value of\n                    <jats:italic>BCL2<\/jats:italic>\n                    mutations in a large prospective cohort of 252 patients with FL treated with immunochemotherapy in the PRIMA randomized trial. Using a DNA\u2010targeted sequencing approach, we detected amino acid altering mutations in 135 patients (54%) and showed that these mutations were probably mediated by the over\u2010activation of AICDA (activation\u2010induced cytidine deaminase) in the context of the t(14;18) translocation. The BCL2 variants identified in PRIMA patients affected the BH1, BH2, and BH3 functional motifs at a lower frequency than the N\u2010terminus and flexible loop domain, with mostly conservative aminoacid changes. With a median follow\u2010up of 6.7 years, we did not observe any impact of\n                    <jats:italic>BCL2<\/jats:italic>\n                    mutations either on overall survival or progression\u2010free survival.\n                  <\/jats:p>","DOI":"10.1002\/ajh.24701","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T06:13:15Z","timestamp":1488348795000},"page":"515-519","source":"Crossref","is-referenced-by-count":20,"title":["BCL2 mutations do not confer adverse prognosis in follicular lymphoma patients treated with rituximab"],"prefix":"10.1002","volume":"92","author":[{"given":"Sarah","family":"Huet","sequence":"first","affiliation":[{"name":"Service d'h\u00e9matologie biologique, Hospices Civils de Lyon 69495 Pierre B\u00e9nite cedex France"},{"name":"INSERM1052, CNRS 5286, Universit\u00e9 Claude Bernard, Facult\u00e9 de M\u00e9decine Lyon\u2010Sud Charles M\u00e9rieux, Universit\u00e9 de Lyon 69495 Pierre B\u00e9nite cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Szafer\u2010Glusman","sequence":"additional","affiliation":[{"name":"Genentech South San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Tesson","sequence":"additional","affiliation":[{"name":"Institut Carnot CALYM Pierre B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Xerri","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille University and Institut Paoli\u2010Calmettes Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne J.","family":"Fairbrother","sequence":"additional","affiliation":[{"name":"Genentech South San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Mukhyala","sequence":"additional","affiliation":[{"name":"Genentech South San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Bolen","sequence":"additional","affiliation":[{"name":"Genentech South San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Punnoose","sequence":"additional","affiliation":[{"name":"Genentech South San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Tonon","sequence":"additional","affiliation":[{"name":"Synergie Lyon Cancer, Plateforme de bioinformatique 'Gilles Thomas', Centre L\u00e9on B\u00e9rard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Chassagne\u2010Cl\u00e9ment","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre L\u00e9on B\u00e9rard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Feugier","sequence":"additional","affiliation":[{"name":"Department of Hematology Nancy University Hospital Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Viari","sequence":"additional","affiliation":[{"name":"Synergie Lyon Cancer, Plateforme de bioinformatique 'Gilles Thomas', Centre L\u00e9on B\u00e9rard Lyon France"},{"name":"Equipe Erable, INRIA Grenoble\u2010Rh\u00f4ne\u2010Alpes Montbonnot\u2010Saint Martin France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Jardin","sequence":"additional","affiliation":[{"name":"Department of Hematology Henri Becquerel Comprehensive Cancer Center and Normandie Univ, UNIROUEN, Inserm U1245, Team \u201cGenomics and biomarkers in lymphoma and solid tumors\u201d Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Salles","sequence":"additional","affiliation":[{"name":"INSERM1052, CNRS 5286, Universit\u00e9 Claude Bernard, Facult\u00e9 de M\u00e9decine Lyon\u2010Sud Charles M\u00e9rieux, Universit\u00e9 de Lyon 69495 Pierre B\u00e9nite cedex France"},{"name":"Service d'h\u00e9matologie clinique, Hospices Civils de Lyon 69495 Pierre B\u00e9nite cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1724-4792","authenticated-orcid":false,"given":"Pierre","family":"Sujobert","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie biologique, Hospices Civils de Lyon 69495 Pierre B\u00e9nite cedex France"},{"name":"INSERM1052, CNRS 5286, Universit\u00e9 Claude Bernard, Facult\u00e9 de M\u00e9decine Lyon\u2010Sud Charles M\u00e9rieux, Universit\u00e9 de Lyon 69495 Pierre B\u00e9nite cedex 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