{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:06:14Z","timestamp":1790910374157,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"AIRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>The most frequent BCR\u2010ABL1 fusion transcripts in chronic myeloid leukemia (CML) are the e13a2 (b2a2) and the e14a2 (b3a2) ones. In the imatinib era few studies addressing the prognostic significance of the BCR\u2010ABL1 transcript type in early chronic phase CML have been published. Overall, these studies suggest that in e14a2 patients the response to imatinib is faster and deeper. To evaluate if the BCR\u2010ABL1 transcript type (e13a2 compared to e14a2) affect the response to imatinib and the clinical outcome in newly diagnosed adult CML patients, 559 patients enrolled in 3 prospective studies (NCT00514488, NCT00510926, observational study CML\/023) were analyzed. A qualitative PCR was performed at baseline: 52% patients had a e14a2 transcript, 37% a e13a2 transcript, 11% co\u2010expressed both transcripts and 1% had other rare transcripts. The median follow\u2010up was 76 months (95% of the patients had at least a 5\u2010year observation). The complete cytogenetic response rates were comparable in e14a2 and e13a2 patients. The median time to MR<jats:sup>3.0<\/jats:sup>(6 and 12 months) and MR<jats:sup>4.0<\/jats:sup>(41 and 61 months) was significantly shorter for e14a2 patients compared to e13a2 patients, with a higher cumulative probability of MR<jats:sup>3.0<\/jats:sup>(88% and 83%,<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and MR<jats:sup>4.0<\/jats:sup>(67% and 52%,<jats:italic>P<\/jats:italic>\u2009=\u2009.001). The 7\u2010year overall survival (90% and 83%,<jats:italic>P<\/jats:italic>\u2009=\u2009.017), progression\u2010free survival (89% and 81%,<jats:italic>P<\/jats:italic>\u2009=\u2009.005) and failure\u2010free survival (71% and 54%,<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) were significantly better in patients with e14a2 transcript. In conclusion, patients with e13a2 transcript had a slower molecular response with inferior response rates to imatinib and a poorer long\u2010term outcome.<\/jats:p>","DOI":"10.1002\/ajh.24774","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:16:39Z","timestamp":1493770599000},"page":"797-805","source":"Crossref","is-referenced-by-count":83,"title":["The BCR\u2010ABL1 transcript type influences response and outcome in<scp>P<\/scp>hiladelphia chromosome\u2010positive chronic myeloid leukemia patients treated frontline with imatinib"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0602-2628","authenticated-orcid":false,"given":"Fausto","family":"Castagnetti","sequence":"first","affiliation":[{"name":"Institute of Hematology \u201cL. and A. Ser\u00e0gnoli\u201d, Department of Experimental, Diagnostic and Specialty Medicine \u201cS.Orsola\u2010Malpighi\u201d University Hospital, University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Gugliotta","sequence":"additional","affiliation":[{"name":"Institute of Hematology \u201cL. and A. Ser\u00e0gnoli\u201d, Department of Experimental, Diagnostic and Specialty Medicine \u201cS.Orsola\u2010Malpighi\u201d University Hospital, University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Breccia","sequence":"additional","affiliation":[{"name":"Hematology Unit, Department of Cellular Biotechnologies and Hematology \u201cLa Sapienza\u201d University Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7958-4966","authenticated-orcid":false,"given":"Alessandra","family":"Iurlo","sequence":"additional","affiliation":[{"name":"Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Levato","sequence":"additional","affiliation":[{"name":"Hematology Unit, \u201cPugliese\u2010Ciaccio\u201d Hospital Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Albano","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Vigneri","sequence":"additional","affiliation":[{"name":"Unit of Medical Oncology, A.O.U. 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