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We analyzed patients receiving an AHCT for multiple myeloma or lymphoma in a contemporary cohort (2010\u20132012), with consistent treatment and supportive care and compared outcomes [CTCAE grade 3\u20135 toxicities, nonrelapse mortality (NRM) and overall\u2010survival (OS)] of younger (40\u201359 years, <jats:italic>n<\/jats:italic>\u2009=\u200977) versus older (\u226560 years, <jats:italic>n<\/jats:italic>\u2009=\u200967) recipients. The proportion of patients with neutropenic infections was higher in the older group (64% vs. 44%; <jats:italic>P<\/jats:italic>\u2009=\u20090.02). The proportion of patients with any grade 3\u20135 toxicity was also higher in the older group (84% vs. 67%, <jats:italic>P<\/jats:italic>\u2009=\u20090.03). In multivariate analysis, older age was significantly associated with higher odds (OR: 2.57, 95% CI:1.09\u20136.05) of grade 3\u20135 toxicity. The NRM was 3% (older) vs. 0% (younger) at 1 year. The probability of OS at 2 years was lower in the older group (76% vs. 90%, <jats:italic>P<\/jats:italic>\u2009=\u20090.04). Though AHCT can be performed safely in older recipients, the higher toxicity and slightly higher NRM in this population needs attention. Studies focusing on risk\u2010stratification in older patients would further help predict toxicity. Further studies addressing enhanced supportive care needs for older patients who are most likely to benefit are indicated.<\/jats:p>","DOI":"10.1002\/ajh.24814","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:16:40Z","timestamp":1497399400000},"source":"Crossref","is-referenced-by-count":8,"title":["Transplantation related toxicity and mortality in older autologous hematopoietic cell transplantation recipients"],"prefix":"10.1002","volume":"92","author":[{"given":"Hewan","family":"Belete","sequence":"first","affiliation":[{"name":"Division of Hematology University of Minnesota, Oncology and Transplantation Minneapolis Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda J.","family":"Burns","sequence":"additional","affiliation":[{"name":"Health Services Research, National Marrow Donor Program Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Shanley","sequence":"additional","affiliation":[{"name":"Division of Hematology University of Minnesota, Oncology and Transplantation Minneapolis Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manju","family":"Nayar","sequence":"additional","affiliation":[{"name":"Division of Hematology University of Minnesota, Oncology and Transplantation Minneapolis Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"McClune","sequence":"additional","affiliation":[{"name":"Division of Hematology University of Minnesota, Oncology and Transplantation Minneapolis Minnesota 55455"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandr","family":"Lazaryan","sequence":"additional","affiliation":[{"name":"Division of Hematology University of Minnesota, Oncology and Transplantation Minneapolis Minnesota 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