{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:57:00Z","timestamp":1771027020752,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T00:00:00Z","timestamp":1501286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The study had no external sources of funding"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prognostic factors among acute myeloid leukemia (AML) patients undergoing allogeneic hematopoietic cell transplantation (allo\u2010HCT) in minimal residual disease (MRD)\u2010negative first complete remission (CR1) are unknown. We retrospectively attempted to answer the following question: In AML patients undergoing allo\u2010HCT in MRD\u2010negative CR1, does a history of prior consolidation provide additional prognostic information?<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The inclusion criteria were: (<jats:italic>i<\/jats:italic>) Age\u2009&gt;\u200918 years, (<jats:italic>ii<\/jats:italic>) AML in CR1 after 1\u20102 cycles of intensive induction chemotherapy, with or without consolidation, (<jats:italic>iii<\/jats:italic>) Allo\u2010HCT between 1\/2003 and 4\/2016 at our institution, (<jats:italic>iv<\/jats:italic>) Available standard\u2010sensitivity 4\u2010color flow cytometry results from a bone marrow aspiration at diagnosis and after completion of all previous chemotherapy within one month prior to HCT, (<jats:italic>v<\/jats:italic>) Flow cytometry\u2010based MRD\u2010negative status at the time of HCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A history of prior consolidation was associated with favorable overall survival (Hazard Ratio [95% Confidence Interval]: 0.59 [0.35\u20100.99], <jats:italic>P<\/jats:italic>\u2009=\u2009.046), relapse\u2010free survival (0.60 [0.37\u20100.96], <jats:italic>P<\/jats:italic>\u2009=\u2009.036), and relapse (0.50 [0.27\u20100.92], <jats:italic>P<\/jats:italic>\u2009=\u2009.025). Analysis of potential sources of bias was unrevealing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In AML patients undergoing allo\u2010HCT in MRD\u2010negative CR1, a history of prior consolidation was associated with favorable outcomes. If the path to pre\u2010HCT MRD negativity includes consolidation, it may identify patients with improved prognosis following HCT in MRD\u2010negative state. These results warrant validation in larger cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajh.24834","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T08:38:39Z","timestamp":1498293519000},"page":"1032-1036","source":"Crossref","is-referenced-by-count":11,"title":["History of consolidation is prognostic in acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplantation in minimal residual disease\u2010negative first complete remission"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9384-272X","authenticated-orcid":false,"given":"Armin","family":"Rashidi","sequence":"first","affiliation":[{"name":"Division of Hematology Oncology, and Transplantation, Department of Medicine, University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Linden","sequence":"additional","affiliation":[{"name":"Division of Hematopathology Department of Laboratory Medicine and Pathology, University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd E.","family":"DeFor","sequence":"additional","affiliation":[{"name":"Biostatistics Core, Masonic Cancer Center, University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Warlick","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, and Transplantation, Department of Medicine, University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelli","family":"Bejanyan","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, and Transplantation, Department of Medicine, University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Yohe","sequence":"additional","affiliation":[{"name":"Division of Hematopathology Department of Laboratory Medicine and Pathology, University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Weisdorf","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, and Transplantation, Department of Medicine, University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-6213","authenticated-orcid":false,"given":"Celalettin","family":"Ustun","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, and Transplantation, Department of Medicine, University of Minnesota Minneapolis 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