{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:16:01Z","timestamp":1740104161892,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T00:00:00Z","timestamp":1501286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hematopoietic stem cell (HSC) release is positively regulated by the sympathetic nervous system through the \u03b23 adrenergic receptor. Preclinical studies have demonstrated that the combination of desipramine and G\u2010CSF resulted in improved HSC mobilization. Here, we present the results of an open\u2010label single\u2010arm pilot study in patients with multiple myeloma undergoing autologous stem cell transplantation (ASCT) to assess the safety and efficacy of desipramine combined with G\u2010SCF to induce HSC mobilization. The primary endpoint was safety of the combination including engraftment kinetics. The secondary endpoint was the proportion of patients who collected \u22655 \u00d7 10<jats:sup>6<\/jats:sup> CD34<jats:sup>+<\/jats:sup> cells\/kg. Outcomes were compared with historical matched controls during the same time period with multiple myeloma mobilized with G\u2010CSF. All study patients received desipramine 100 mg daily for 7 days, starting 4 days prior to G\u2010CSF administration (D\u20103) and continued taking it along with G\u2010CSF for a total of 7 days. Six of ten patients enrolled completed the protocol with minimal side effects. All of them achieved the target collection of 5 \u00d7 10<jats:sup>6<\/jats:sup> CD34 cells\/kg in a median of 1.5 apheresis session with two patients needing additional plerixafor (16%), while 11 out of 13 patients (85%) achieved the target of 5 \u00d7 10<jats:sup>6<\/jats:sup> CD34 cells\/kg in the historical control group in a median of 2 apheresis procedures and seven patients needed plerixafor (54%). The combination of desipramine and G\u2010CSF is safe and signals improved mobilization over G\u2010CSF alone, providing a possible alternative means of mobilization that needs further investigation.<\/jats:p>","DOI":"10.1002\/ajh.24843","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T13:25:53Z","timestamp":1499174753000},"page":"1047-1051","source":"Crossref","is-referenced-by-count":12,"title":["Stimulation of adrenergic activity by desipramine enhances hematopoietic stem and progenitor cell mobilization along with G\u2010CSF in multiple myeloma: A pilot study"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3650-0800","authenticated-orcid":false,"given":"Aditi","family":"Shastri","sequence":"first","affiliation":[{"name":"Department of Oncology Montefiore Medical Center\/Albert Einstein College of Medicine  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Budhathoki","sequence":"additional","affiliation":[{"name":"Department of Oncology Montefiore Medical Center\/Albert Einstein College of Medicine  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan K.","family":"Barta","sequence":"additional","affiliation":[{"name":"Department of Oncology Fox Chase Cancer Center  Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah","family":"Kornblum","sequence":"additional","affiliation":[{"name":"Department of Oncology Montefiore Medical Center\/Albert Einstein College of Medicine  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Derman","sequence":"additional","affiliation":[{"name":"Department of Oncology Montefiore Medical Center\/Albert Einstein College of Medicine  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramakrishna","family":"Battini","sequence":"additional","affiliation":[{"name":"Department of Oncology Montefiore Medical Center\/Albert Einstein College of Medicine  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radha","family":"Raghupathy","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Chinese University of Hong Kong Shatin NT Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit K.","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Oncology Montefiore Medical Center\/Albert Einstein College of Medicine  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Frenette","sequence":"additional","affiliation":[{"name":"Department of Cell Biology Albert Einstein College of Medicine  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Braunschweig","sequence":"additional","affiliation":[{"name":"Department of Oncology Montefiore Medical Center\/Albert Einstein College of Medicine  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9323-8007","authenticated-orcid":false,"given":"Murali","family":"Janakiram","sequence":"additional","affiliation":[{"name":"Department of Oncology Montefiore Medical Center\/Albert Einstein College of Medicine  New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09262"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.10.041"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05390.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-367102"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.07.011"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101688"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101700"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.370"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.07.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1547"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.05.017"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-174946"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.24843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.24843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.24843","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.24843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T03:39:46Z","timestamp":1694921986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.24843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,29]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/ajh.24843"],"URL":"https:\/\/doi.org\/10.1002\/ajh.24843","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"type":"print","value":"0361-8609"},{"type":"electronic","value":"1096-8652"}],"subject":[],"published":{"date-parts":[[2017,7,29]]}}}