{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:20:38Z","timestamp":1790112038225,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T00:00:00Z","timestamp":1501286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Organ damage in sickle cell disease (SCD) is a crucial determinant for disease severity and prognosis. In a previous study, we analyzed the prevalence of SCD\u2010related organ damage and complications in adult sickle cell patients. We now describe a seven\u2010year follow\u2010up of this cohort.All patients from the primary analysis in 2006 (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009104), were included for follow\u2010up. Patients were screened for SCD\u2010related organ damage and complications (microalbuminuria, renal failure, elevated tricuspid regurgitation flow velocity (TRV) (\u22652.5 m\/seconds), retinopathy, iron overload, cholelithiasis, avascular osteonecrosis, leg ulcers, acute chest syndrome (ACS), stroke, priapism and admissions for vaso\u2010occlusive crises (VOC) biannually. Upon 7 years of follow\u2010up, progression in the prevalence of avascular osteonecrosis (from 12.5% to 20.4%), renal failure (from 6.7% to 23.4%), retinopathy (from 39.7% to 53.8%) was observed in the whole group. In HbSS\/HbS\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    \u2010thal patients also progression in microalbuminuria (from 34% to 45%) and elevated TRV (from 40% to 48%) was observed while hardly any progression in the prevalence of cholelithiasis, priapism, stroke or chronic ulcers was seen. The proportion of patients with at least one episode of ACS increased in the group of HbSS\/HbS\u03b2\n                    <jats:sup>0<\/jats:sup>\n                    \u2010thal patients from 32% to 49.1%. In conclusion, 62% of the sickle cell patients in this prospective cohort study developed a new SCD\u2010related complication in a comprehensive care setting within 7 years of follow\u2010up. Although the hospital admission rate for VOC remained stable, multiple forms of organ damage increased substantially. These observations underline the need for continued screening for organ damage in all adult patients with SCD.\n                  <\/jats:p>","DOI":"10.1002\/ajh.24855","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T22:18:01Z","timestamp":1499811481000},"source":"Crossref","is-referenced-by-count":31,"title":["Prospective evaluation of chronic organ damage in adult sickle cell patients: A seven\u2010year follow\u2010up study"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-5267","authenticated-orcid":false,"given":"Charlotte F. J.","family":"van Tuijn","sequence":"first","affiliation":[{"name":"Department of Hematology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marein","family":"Schimmel","sequence":"additional","affiliation":[{"name":"Department of Hematology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3934-7189","authenticated-orcid":false,"given":"Eduard J.","family":"van Beers","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek, University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erfan","family":"Nur","sequence":"additional","affiliation":[{"name":"Department of Hematology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart J.","family":"Biemond","sequence":"additional","affiliation":[{"name":"Department of Hematology Academic Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"179","article-title":"Peculiar elongated and sickle\u2010shaped red blood corpuscles in a case of severe anemia. 1910","volume":"74","author":"Herrick JB.","year":"2001","journal-title":"Yale J Biol 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