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For patients with disease limited to the skin, expectant management or skin\u2010directed therapies is preferred, as both disease\u2010specific and overall survival for these patients is favorable. In contrast, patients with advanced\u2010stage disease with significant nodal, visceral or blood involvement are generally approached with biologic\u2010response modifiers or histone deacetylase inhibitors prior to escalating therapy to include systemic, single\u2010agent chemotherapy. 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