{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:45:44Z","timestamp":1793652344234,"version":"4.5.1"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["APR 2011\u20102014"],"award-info":[{"award-number":["APR 2011\u20102014"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201011\u2010BSV1\u20100024"],"award-info":[{"award-number":["ANR\u201011\u2010BSV1\u20100024"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Delayed hemolytic transfusion reaction (DHTR) is a life\u2010threatening complication of transfusion in sickle cell disease (SCD). The frequency of DHTR is underestimated because its symptoms mimic those of vaso\u2010occlusive crisis and antibodies (Abs) are often not detectable. No predictive factors for identifying patients likely to develop DHTR have yet been defined. We conducted a prospective single\u2010center observational study over 30 months in adult sickle cell patients. We included 694 transfusion episodes (TEs) in 311 patients, divided into occasional TEs (OTEs: 360) and chronic transfusion program (CTEs: 334). During follow\u2010up, 15 cases of DHTR were recorded, exclusively after OTEs. DHTR incidence was 4.2% per OTE (95% CI [2.6; 6.9]) and 6.8% per patient during the 30 months of the study (95% CI [4.2; 11.3]). We studied 11 additional DHTR cases, to construct a predictive score for DHTR. The DHTR mortality is high, 3 (11.5%) of the 26 DHTR patients died. The variables retained in the multivariate model were history of DHTR, number of units previously transfused and immunization status before transfusion. The resulting DHTR\u2010predictive score had an area under the ROC curve of 0.850 [95% CI: 0.780\u20100.930], a negative\u2010predictive value of 98.4% and a positive\u2010predictive value of 50%. We report in our study population, for the first time, the incidence of DHTR, and, its occurrence exclusively in occasionally transfused patients. We also describe a simple score for predicting DHTR in patients undergoing occasional transfusion, to facilitate the management of blood transfusion in SCD patients.<\/jats:p>","DOI":"10.1002\/ajh.24908","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T06:26:37Z","timestamp":1505802397000},"page":"1340-1348","source":"Crossref","is-referenced-by-count":116,"title":["Incidence and predictive score for delayed hemolytic transfusion reaction in adult patients with sickle cell disease"],"prefix":"10.1002","volume":"92","author":[{"given":"David","family":"Narbey","sequence":"first","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang Cr\u00e9teil 94000 France"},{"name":"Institut Mondor de Recherche Biom\u00e9dicale, lnserm U955, Equipe 2 Cr\u00e9teil 94000 France"},{"name":"Laboratory of Excellence GR\u2010Ex Paris F75739 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoosha","family":"Habibi","sequence":"additional","affiliation":[{"name":"Institut Mondor de Recherche Biom\u00e9dicale, lnserm U955, Equipe 2 Cr\u00e9teil 94000 France"},{"name":"Laboratory of Excellence GR\u2010Ex Paris F75739 France"},{"name":"Reference Center for Sickle Cell Disease, H\u00f4pital Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0757-4309","authenticated-orcid":false,"given":"Philippe","family":"Chadebech","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang Cr\u00e9teil 94000 France"},{"name":"Institut Mondor de Recherche Biom\u00e9dicale, lnserm U955, Equipe 2 Cr\u00e9teil 94000 France"},{"name":"Laboratory of Excellence GR\u2010Ex Paris F75739 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Mekontso\u2010Dessap","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, H\u00f4pital Henri Mondor Cr\u00e9teil France"},{"name":"IMRB, Groupe de recherche clinique CARMAS Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, Facult\u00e9 de M\u00e9decine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Khellaf","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, Facult\u00e9 de M\u00e9decine"},{"name":"Emergency Unit, H\u00f4pital Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Daniel","family":"Leli\u00e8vre","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, Facult\u00e9 de M\u00e9decine"},{"name":"Clinical Immunology Department H\u00f4pital Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Godeau","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, H\u00f4pital Henri Mondor Cr\u00e9teil France"},{"name":"Internal Medicine Department H\u00f4pital Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Michel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, Facult\u00e9 de M\u00e9decine"},{"name":"Internal Medicine Department H\u00f4pital Henri Mondor Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Galact\u00e9ros","sequence":"additional","affiliation":[{"name":"Institut Mondor de Recherche Biom\u00e9dicale, lnserm U955, Equipe 2 Cr\u00e9teil 94000 France"},{"name":"Laboratory of Excellence GR\u2010Ex Paris F75739 France"},{"name":"Reference Center for Sickle Cell Disease, H\u00f4pital Henri Mondor Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, Facult\u00e9 de M\u00e9decine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Djoudi","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang Cr\u00e9teil 94000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Bartolucci","sequence":"additional","affiliation":[{"name":"Institut Mondor de Recherche Biom\u00e9dicale, lnserm U955, Equipe 2 Cr\u00e9teil 94000 France"},{"name":"Laboratory of Excellence GR\u2010Ex Paris F75739 France"},{"name":"Reference Center for Sickle Cell Disease, H\u00f4pital Henri Mondor Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, Facult\u00e9 de M\u00e9decine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3547-3994","authenticated-orcid":false,"given":"France","family":"Pirenne","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang Cr\u00e9teil 94000 France"},{"name":"Institut Mondor de Recherche Biom\u00e9dicale, lnserm U955, Equipe 2 Cr\u00e9teil 94000 France"},{"name":"Laboratory of Excellence GR\u2010Ex Paris F75739 France"},{"name":"Universit\u00e9 Paris Est Cr\u00e9teil, Facult\u00e9 de M\u00e9decine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13339"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006073222301"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00007.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22985"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.104703"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2008.10.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.038307"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-490623"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13123"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37497265337.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01693.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02199.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2015.06.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13494"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24460"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-669770"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12445"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-2-231"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.6.e661"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12875"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24537"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24397"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-784876"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys142"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5001.1071"},{"issue":"8","key":"e_1_2_8_28_1","first-page":"14","article-title":"Cumulative incidence and incidence rate","volume":"108","author":"El\u2010Masri MM.","year":"2012","journal-title":"Can Nurse."},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-3-199302010-00009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2013.05.008"},{"key":"e_1_2_8_31_1","first-page":"561","article-title":"\u00c9valuation des r\u00e8gles de d\u00e9cision clinique","volume":"48","author":"Giraudeau B","year":"2000","journal-title":"Revue D'\u00c9pid\u00e9miologie Et De Sant\u00e9 Publique."},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509263131306"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7019.1539"},{"issue":"2","key":"e_1_2_8_34_1","first-page":"94","article-title":"Comment \u00e9labore\u2010t\u2010on un score clinique, un score de risque?","volume":"39","author":"Laporte S.","year":"2014","journal-title":"JRDIA."},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.1.92"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.015014"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1499-3872(15)60362-9"},{"issue":"12","key":"e_1_2_8_38_1","first-page":"916","article-title":"Is there a place for the Glasgow\u2010Blatchford score in the management of upper gastrointestinal bleeding?","volume":"89","author":"Jerraya H","year":"2011","journal-title":"Tunis Med."},{"key":"e_1_2_8_39_1","unstructured":"LambertJ LipkovichI. A Macro For Getting More Out Of Your ROC Curve. SAS Global Forum 2008."},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780091109"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780100805"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.7418"},{"issue":"2","key":"e_1_2_8_44_1","first-page":"487","article-title":"Validation des \u00e9preuves s\u00e9rologiques pour le diagnostic des maladies infectieuses","volume":"17","author":"Jacobson RH.","year":"1998","journal-title":"Rev Sci Tech Off Int Epiz."},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2011.01517.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12217"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13379"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.24908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.24908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:28:59Z","timestamp":1695572939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.24908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,31]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/ajh.24908"],"URL":"https:\/\/doi.org\/10.1002\/ajh.24908","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,31]]}}}