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Given its activity in relapsed and refractory T acute lymphoblastic leukemia (T\u2010ALL) and T lymphoblastic lymphoma (T\u2010LBL), we sought to define its role in the frontline treatment of adult patients. Therefore, we conducted a single arm phase 2 study to determine the safety and efficacy of nelarabine in combination with hyper\u2010CVAD in newly diagnosed patients. For induction\/consolidation, patients received eight cycles of hyper\u2010CVAD alternating with high\u2010dose methotrexate and cytarabine plus two cycles of nelarabine given at a dose of 650 mg\/m<jats:sup>2<\/jats:sup> intravenously daily for 5 days. This was followed by thirty months of POMP maintenance chemotherapy with two additional cycles of nelarabine given instead of cycles 6 and 7 of POMP maintenance. Sixty\u2010seven patients, including 40 with T\u2010ALL and 26 with T\u2010LBL, were enrolled. Complete response rates in both T\u2010ALL and T\u2010LBL were 87% and 100% respectively. Grade 3 to 4 neurotoxic adverse events were reported in 5 patients. There were 21 relapses (31%) including 2 after allogeneic stem cell transplantation. Median duration of follow\u2010up was 42.5 months. The 3\u2010year complete remission duration (CRD) and overall survival (OS) rates were 66% and 65%, respectively. Compared to our historic hyper\u2010CVAD data, there was no survival benefit with the addition of nelarabine. In conclusion, hyper\u2010CVAD plus nelarabine was well tolerated and active in the frontline treatment of adult T\u2010ALL\/LBL patients.<\/jats:p>","DOI":"10.1002\/ajh.24947","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T07:02:46Z","timestamp":1508396566000},"page":"91-99","source":"Crossref","is-referenced-by-count":102,"title":["Hyper\u2010CVAD plus nelarabine in newly diagnosed adult T\u2010cell acute lymphoblastic leukemia and T\u2010lymphoblastic lymphoma"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-7912","authenticated-orcid":false,"given":"Yasmin","family":"Abaza","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-3307","authenticated-orcid":false,"given":"Hagop","family":"M. 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