{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:16Z","timestamp":1786976836165,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["129084\u2010RSG\u201016\u2010045\u201001\u2010LIB"],"award-info":[{"award-number":["129084\u2010RSG\u201016\u2010045\u201001\u2010LIB"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["6503\u201016"],"award-info":[{"award-number":["6503\u201016"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Optimal salvage therapy for primary refractory peripheral T\u2010cell lymphomas (PTCL) and the role of hematopoietic stem cell transplant (SCT) remain poorly defined. We conducted a retrospective review of clinical outcomes and prognostic factors in a single\u2010center cohort of 93 patients with primary refractory PTCL, defined as progression during first\u2010line therapy or relapse within 6 months of its completion. Clinical outcomes were poor in this population, with median event\u2010free survival (EFS) of 3.5 months, median overall survival (OS) of 9.1 months, and 34% 3\u2010year survival. Outcomes were comparable in patients who progressed through first\u2010line therapy and patients who achieved CR\/PR and subsequently relapsed within 6 months. A majority exhibited high\u2010risk features and had intermediate to high risk IPI, which correlated with inferior outcomes. There was no difference in outcomes between patients who received single\u2010agent salvage regimens and patients who underwent traditional, multi\u2010agent salvage regimens. Thus, participation in well\u2010designed clinical trials should be encouraged in this population. Additionally, there may be a trend toward improved EFS and OS in patients who underwent autologous or allogeneic SCT compared to patients who achieved CR or PR but were not transplanted.<\/jats:p>","DOI":"10.1002\/ajh.24992","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T04:14:55Z","timestamp":1512101695000},"page":"394-400","source":"Crossref","is-referenced-by-count":28,"title":["Survival following salvage therapy for primary refractory peripheral T\u2010cell lymphomas (PTCL)"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0459-2635","authenticated-orcid":false,"given":"Janie Y.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Briski","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumana","family":"Devata","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tycel J.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tera L.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathanael G.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-0760","authenticated-orcid":false,"given":"Ryan A.","family":"Wilcox","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.7524"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.963078"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu443"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.2719"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.9024"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2320"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-7-11"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-312603"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13222"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.2782"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.0402"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.0410"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.2456"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","unstructured":"BelleiM FossFM HorwitzSM et al. The Outcome of Patients with Primary Refractory or Relapsed Peripheral T\u2010Cell Lymphoma: Analysis of 1020 Cases Registered in the Prospective T\u2010Cell Project [abstract]. American Society of Hematology. 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