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Bone marrow fibrosis (BMF) is associated with several malignant and nonmalignant pathologies severely affecting blood cell production. BMF results from abnormal deposition of collagen fibers and enhanced lysyl oxidase\u2010mediated ECM crosslinking within the marrow, thereby increasing marrow stiffness. Bone marrow stiffness has been recently recognized as an important regulator of blood cell development, notably by modifying the fate and differentiation process of hematopoietic or mesenchymal stem cells. This review surveys the different components of the ECM and their influence on stem cell development, with a focus on the impact of the ECM composition and stiffness on the megakaryocytic lineage in health and disease. Megakaryocyte maturation and the biogenesis of their progeny, the platelets, are thought to respond to environmental mechanical forces through a number of mechanosensors, including integrins and mechanosensitive ion channels, reviewed here.<\/jats:p>","DOI":"10.1002\/ajh.25008","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T22:52:15Z","timestamp":1513464735000},"page":"430-441","source":"Crossref","is-referenced-by-count":77,"title":["The role of extracellular matrix stiffness in megakaryocyte and platelet development and function"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3006-6380","authenticated-orcid":false,"given":"Orly","family":"Leiva","sequence":"first","affiliation":[{"name":"Department of Medicine Whitaker Cardiovascular Institute, Boston University School of Medicine Boston 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