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Realizing Effectiveness Across Continents with Hydroxyurea (REACH, ClinicalTrials.gov NCT01966731) is a prospective, Phase I\/II open\u2010label trial of hydroxyurea designed to evaluate the feasibility, safety, and benefits of hydroxyurea treatment for children with SCA in four sub\u2010Saharan African countries. Following comprehensive training of local research teams, REACH was approved by local Ethics Committees and achieved full enrollment ahead of projections with 635 participants enrolled over a 30\u2010month period, despite half of families living &gt;12 km from their clinical site. At enrollment, study participants (age 5.4\u2009\u00b1\u20092.4 years) had substantial morbidity, including a history of vaso\u2010occlusive pain (98%), transfusion (68%), malaria (85%), and stroke (6%). Significant differences in laboratory characteristics were noted across sites, with lower hemoglobin concentrations (P\u2009&lt;\u2009.01) in Angola (7.2\u2009\u00b1\u20091.0 g\/dL) and the DRC (7.0\u2009\u00b1\u20090.9 g\/dL) compared to Kenya (7.4\u2009\u00b1\u20091.1 g\/dL) and Uganda (7.5\u2009\u00b1\u20091.1 g\/dL). Analysis of known genetic modifiers of SCA demonstrated a high frequency of \u03b1\u2010thalassemia (58.4% with at least a single \u03b1\u2010globin gene deletion) and G6PD deficiency (19.7% of males and 2.4% of females) across sites. The CAR \u03b2\u2010globin haplotype was present in 99% of participants. The full enrollment to REACH confirms the feasibility of conducting high\u2010quality SCA research in Africa; this study will provide vital information to guide safe and effective dosing of hydroxyurea for children with SCA living in Africa.<\/jats:p>","DOI":"10.1002\/ajh.25034","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T15:48:28Z","timestamp":1515599308000},"page":"537-545","source":"Crossref","is-referenced-by-count":37,"title":["Realizing effectiveness across continents with hydroxyurea: Enrollment and baseline characteristics of the multicenter REACH study in Sub\u2010Saharan Africa"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6198-4785","authenticated-orcid":false,"given":"Patrick T.","family":"McGann","sequence":"first","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati 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