{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:10:45Z","timestamp":1763017845227,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute myeloid leukemia (AML) patients harboring the <jats:italic>FLT3\u2010ITD<\/jats:italic> mutation are considered a high risk patient subset preferentially allocated for allogeneic stem cell transplantation in first remission. Whether <jats:italic>FLT3\u2010ITD<\/jats:italic> retains a prognostic role in haploidentical stem cell transplantation (haplo\u2010SCT) is unknown. To analyze the prognostic impact of <jats:italic>FLT3\u2010ITD<\/jats:italic> in haplo\u2010SCT, we performed a retrospective analysis of the multicenter registry of the acute leukemia working party of the European Society for Blood and Marrow Transplantation. We included all adult AML patients with known <jats:italic>FLT3<\/jats:italic> status who underwent a first T\u2010cell replete related haplo\u2010HCT in first complete remission from 2005 to 2016. We evaluated 293 patients of whom 202 were <jats:italic>FLT3<\/jats:italic><jats:sup>wt<\/jats:sup> and 91 were <jats:italic>FLT3\u2010ITD<\/jats:italic> mutated. <jats:italic>FLT3\u2010ITD<\/jats:italic> patients were more likely to be <jats:italic>NPM1<\/jats:italic> mutated as well as be in the intermediate risk cytogenetic risk category. In multivariate analysis, patients with <jats:italic>FLT3\u2010ITD<\/jats:italic> had comparable rates of relapse incidence [Hazard ratio (HR)\u2009=\u20091.34, confidence interval (CI) 95%, 0.67\u20102.7; <jats:italic>P<\/jats:italic>\u2009=\u2009.9] and leukemia\u2010free survival (HR\u2009=\u20090.99, CI 95%, 0.62\u20101.57; <jats:italic>P<\/jats:italic>\u2009=\u2009.9) to those of <jats:italic>FLT3<\/jats:italic><jats:sup>wt<\/jats:sup> patients. Overall survival, the incidence of nonrelapse mortality, and graft versus host disease\u2010free\/relapse\u2010free survival were not significantly impacted by <jats:italic>FLT3\u2010ITD<\/jats:italic> status. Furthermore, relapse and overall survival were comparable between <jats:italic>FLT3\u2010ITD<\/jats:italic> patients transplanted from various donor pools, namely matched siblings, unrelated donors, haplo\u2010SCT). Finally, subset analysis of patients with intermediate risk cytogenetics confirmed the absence of a prognostic impact of <jats:italic>FLT3\u2010ITD<\/jats:italic> also for this patient segment. In AML patients undergoing T\u2010cell replete haplo\u2010SCT, the <jats:italic>FLT3\u2010ITD<\/jats:italic> mutation possibly does not retain its prognostic significance.<\/jats:p>","DOI":"10.1002\/ajh.25082","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T09:10:40Z","timestamp":1519981840000},"page":"736-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["T\u2010cell replete haploidentical stem cell transplantation attenuates the prognostic impact of <i>FLT3\u2010ITD<\/i> in acute myeloid leukemia: A report from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5294-3524","authenticated-orcid":false,"given":"Jonathan","family":"Canaani","sequence":"first","affiliation":[{"name":"Chaim Sheba Medical Center, Hematology Division Tel Aviv University Tel\u2010Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"Acute Leukemia Working Party \u2013 EBMT and Department of Hematology and Cell Therapy H\u00f4pital Saint\u2010Antoine Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University Peopl\u00e9s Hospital, Institute of Haematology, Xicheng District Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Arcese","sequence":"additional","affiliation":[{"name":"Tor Vergat\u00e4 University of Rome, Stem Cell Transplant Unit, Policlinico Universitario Tor Vergata Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ciceri","sequence":"additional","affiliation":[{"name":"Ospedale San Raffaele s.r.l., Haematology and BMT Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Blaise","sequence":"additional","affiliation":[{"name":"Programme de Transplantation&amp;Therapie Cellulaire, Centre de Recherche en Canc\u00e9rologie de Marseille, Institut Paoli Calmettes Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Irrera","sequence":"additional","affiliation":[{"name":"Centro Unico Regionale Trapianti Azienda Ospedaliera Alberto Neri Reggio Calabria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Lopez","family":"Corral","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico, Servicio de Hematolog\u00eda Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetto","family":"Bruno","sequence":"additional","affiliation":[{"name":"S.S.C.V.D Trapianto di Cellule Staminali, A.O.U Citta della Salute e della Scienza di Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Santarone","sequence":"additional","affiliation":[{"name":"Ospedale Civile, Dipartimento di Ematologia Medicina Trasfusionale e Biotecnologie Pescara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Van Lint","sequence":"additional","affiliation":[{"name":"Department of Haematology II Ospedale San Martino Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonin","family":"Vitek","sequence":"additional","affiliation":[{"name":"Institute of Hematology and Blood Transfusion Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Esteve","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[{"name":"Acute Leukemia Working Party \u2013 EBMT and Department of Hematology and Cell Therapy H\u00f4pital Saint\u2010Antoine Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon","family":"Nagler","sequence":"additional","affiliation":[{"name":"Chaim Sheba Medical Center, Hematology Division Tel Aviv University Tel\u2010Hashomer Israel"},{"name":"Acute Leukemia Working Party \u2013 EBMT and Department of Hematology and Cell Therapy H\u00f4pital Saint\u2010Antoine Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"7233","article-title":"Absence of the wild\u2010type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study","volume":"61","author":"Whitman SP","year":"2001","journal-title":"Cancer Res."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1752"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1440"},{"key":"e_1_2_6_5_1","first-page":"19","article-title":"Incidence and prognostic value of FLT3 internal tandem duplication and D835 mutations in acute myeloid leukemia","volume":"88","author":"Moreno I","year":"2003","journal-title":"Haematologica."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-12-3627"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.6253"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074306"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-283648"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1323"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-009233"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-047225"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.02.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.06.012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.9868"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-651562"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.09.009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2016.01.005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2014.954543"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.3523"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.08.013"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-639831"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-02-627786"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0394-2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2016002386"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-609032"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703260"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.6"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.07.032"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.90"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-578070"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-733196"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2013.0127"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.128"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-587477"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.08.023"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.01.002"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301689"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516192"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-431122"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.10.023"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.3826"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24632"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.25082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.25082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.25082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.25082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T07:33:30Z","timestamp":1693899210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.25082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,23]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/ajh.25082"],"URL":"https:\/\/doi.org\/10.1002\/ajh.25082","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"type":"print","value":"0361-8609"},{"type":"electronic","value":"1096-8652"}],"subject":[],"published":{"date-parts":[[2018,3,23]]},"assertion":[{"value":"2017-12-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}