{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T20:48:26Z","timestamp":1792356506747,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allogeneic hematopoietic cell transplantation (alloHCT) with myeloablative conditioning based on total body irradiation (TBI) is widely used for the treatment of adults with acute lymphoblastic leukemia (ALL). TBI is most frequently administered in combination with either cyclophosphamide (Cy\/TBI) or etoposide (Vp\/TBI). The goal of this study was to retrospectively compare these two regimens. Adult patients with Ph\u2010negative ALL treated with alloHCT in first or second complete remission who received Cy\/TBI (<jats:italic>n<\/jats:italic>\u2009=\u20091346) or Vp\/TBI (<jats:italic>n<\/jats:italic>\u2009=\u2009152) conditioning were included in the analysis. In a univariate analysis, as compared to Cy\/TBI, the use of Vp\/TBI was associated with reduced incidence of relapse (17% vs. 30% at 5 years, <jats:italic>P<\/jats:italic>\u2009=\u2009.007), increased rate of leukemia\u2010free survival (60% vs. 50%, <jats:italic>P<\/jats:italic>\u2009=\u2009.04), and improved \u201cgraft versus host disease (GVHD) and relapse\u2010free survival\u201d (GRFS, 43% vs. 33%, <jats:italic>P<\/jats:italic>\u2009=\u2009.04). No significant effect could be observed in terms of the incidence of nonrelapse mortality or acute or chronic GVHD. In a multivariate model, the use of Vp\/TBI was associated with reduced risk of relapse (HR\u2009=\u20090.62, <jats:italic>P<\/jats:italic>\u2009=\u2009.04) while the effect on other study end\u2010points was not significant. In conclusion, conditioning regimen based on Vp combined with TBI appears more effective for disease control than the combination of Cy with TBI for adult patients with Ph\u2010negative ALL treated with alloHCT.<\/jats:p>","DOI":"10.1002\/ajh.25091","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T15:11:08Z","timestamp":1521990668000},"page":"778-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Cyclophosphamide versus etoposide in combination with total body irradiation as conditioning regimen for adult patients with Ph\u2010negative acute lymphoblastic leukemia undergoing allogeneic stem cell transplant: On behalf of the ALWP of the European Society for Blood and Marrow Transplantation"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-0182","authenticated-orcid":false,"given":"Anna","family":"Czyz","sequence":"first","affiliation":[{"name":"Wroclaw Medical University Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Labopin","sequence":"additional","affiliation":[{"name":"Hospital St. Antoine Paris France"},{"name":"Acute Leukemia Working Party of the EBMT, Paris office, Hospital St. Antoine Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Giebel","sequence":"additional","affiliation":[{"name":"Maria Sklodowska\u2010Curie Memorial Cancer Center Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Soci\u00e9","sequence":"additional","affiliation":[{"name":"Hopital St. Louis Paris 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Southampton and University of Southampton Southampton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricette","family":"Michallet","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Lyon Sud \u2010 Service Hematologie Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Stuhler","sequence":"additional","affiliation":[{"name":"Deutsche Klinik f\u00fcr Diagnostik KMT Zentrum Wiesbaden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar","family":"Chaganti","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Murray","sequence":"additional","affiliation":[{"name":"Leicester Royal Infirmary Leicester United 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