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We retrospectively analyzed 252 patients aged 80\u2010100 years, diagnosed with DLBCL or grade 3B follicular lymphoma, treated in 19 hospitals from the GELTAMO group. Primary objective was to analyze the influence of the type of treatment and comorbidity scales on progression\u2010free survival (PFS) and overall survival (OS). One hundred sixty\u2010three patients (63%) were treated with chemotherapy that included anthracyclines and\/or rituximab, whereas 15% received no chemotherapeutic treatment. With a median follow\u2010up of 44 months, median PFS and OS were 9.5 and 12.5 months, respectively. In an analysis restricted to the 205 patients treated with any kind of chemotherapy, comorbidity scales did not influence the choice of treatment type significantly. Independent factors associated with better PFS and OS were: age\u2009&lt;\u200986 years, cumulative illness rating scale (CIRS) score\u2009&lt;\u20096, intermediate risk (1\u20102) R\u2010IPI, and treatment with R\u2010CHOP at full or reduced doses. We developed a prognostic model based on the multivariate analysis of the 108 patients treated with R\u2010CHOP\u2010like: median OS was 45 vs. 12 months (<jats:italic>P<\/jats:italic>\u2009=\u2009.001), respectively, for patients with 0\u20101 <jats:italic>vs<\/jats:italic>. 2\u20103 risk factors (age\u2009&gt;\u200985 years, R\u2010IPI 3\u20105 or CIRS\u2009&gt;\u20095). In conclusion, treatment with R\u2010CHOP\u2010like is associated with good survival in a significant proportion of patients. We have developed a simple prognostic model that may aid the selection patients who could benefit from a curative treatment, although it needs to be validated in larger series.<\/jats:p>","DOI":"10.1002\/ajh.25107","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:34:19Z","timestamp":1523838859000},"page":"867-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A new prognostic model identifies patients aged 80 years and older with diffuse large B\u2010cell lymphoma who may benefit from curative treatment: A multicenter, retrospective analysis by the Spanish GELTAMO group"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7712-7876","authenticated-orcid":false,"given":"Emilia","family":"Pardal","sequence":"first","affiliation":[{"name":"Hematology Department Hospital Virgen del Puerto 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