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Pathologic review and an appropriate staging evaluation are necessary to distinguish primary cutaneous B\u2010cell lymphomas from systemic B\u2010cell lymphomas with secondary skin involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Risk stratification<\/jats:title><jats:p>Disease histology remains the most important prognostic determinant. Both PCFCL and PCMZL are indolent lymphomas that infrequently disseminate to extracutaneous sites and are associated with 5\u2010year survival rates that exceed 95%. In contrast, PCDLBCL, LT is an aggressive lymphoma with an inferior prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Risk\u2010adapted therapy<\/jats:title><jats:p>PCFCL and PCMZL patients with solitary or relatively few skin lesions may be affectively managed with local radiation therapy. While single\u2010agent rituximab may be employed for patients with more widespread skin involvement, multiagent chemotherapy is rarely appropriate. 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