{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:22:02Z","timestamp":1792812122672,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Between 1967 and 2017, 361 patients with myeloproliferative neoplasms (MPN), age\u2009\u2264\u200940\u2009years, were seen at our institution, constituting 12% of all MPN patients (<jats:italic>n<\/jats:italic>\u2009=\u20093023) seen during the same time period; disease\u2010specific incidences were 12% in polycythemia vera (PV; <jats:italic>n<\/jats:italic>\u2009=\u200979), 20% in essential thrombocythemia (ET; <jats:italic>n<\/jats:italic>\u2009=\u2009219) and 5% in primary myelofibrosis (PMF; <jats:italic>n<\/jats:italic>\u2009=\u200963). Compared to their older counterparts, younger patients were more likely to present with low risk disease (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and display female preponderance in ET (<jats:italic>P<\/jats:italic>\u2009=\u2009.04), lower incidence of arterial events overall (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and higher incidence of venous thrombosis in PV (<jats:italic>P<\/jats:italic>\u2009=\u2009.01). Younger patients were also more likely to express <jats:italic>CALR<\/jats:italic> mutations, in ET and PMF, normal karyotype, in PV and PMF, and lower incidence of high molecular risk mutations in PMF (<jats:italic>P significant in all instances<\/jats:italic>). Over median follow\u2010up of 11.3, 13, and 7.1 years for PV, ET, and PMF, leukemic transformations were respectively documented in 4%, 2%, and 10% (<jats:italic>P<\/jats:italic> values 0.1\u20100.9) while incidences of fibrotic progression in PV (22%) and ET (16%) were expectedly higher in young patients, because of their longer survival (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Median survival in young patients was 37\u2009years for PV, 35 for ET and 20 for PMF; the corresponding values were 22, 22, and 8\u2009years for ages 41\u201060\u2009years and 10, 11, and 3\u2009years for ages &gt;60\u2009years (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Young MPN patients comprise a unique disease subset defined by an attenuated\u2010risk cytogenetic and mutational backdrop and conspicuously longer survival compared to their older counterparts, which requires assertion during patient counseling.<\/jats:p>","DOI":"10.1002\/ajh.25270","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T09:30:50Z","timestamp":1535621450000},"page":"1474-1484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Myeloproliferative neoplasms in the young: Mayo Clinic experience with 361 patients age 40 years or younger"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-6171","authenticated-orcid":false,"given":"Natasha","family":"Szuber","sequence":"first","affiliation":[{"name":"Divisions of Hematology, Departments of Internal and Laboratory Medicine Mayo Clinic  Rochester 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