{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:38:50Z","timestamp":1790109530841,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T00:00:00Z","timestamp":1540944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R44HL123670"],"award-info":[{"award-number":["R44HL123670"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sickle cell disease (SCD) is a common, life\u2010threatening genetic disorder that is best managed when diagnosed early by newborn screening. However, SCD is most prevalent in low\u2010resource regions of the world where newborn screening is rare and diagnosis at the point\u2010of\u2010care is challenging. In many such regions, the majority of affected children die, undiagnosed, before the age of 5 years. A rapid and affordable point\u2010of\u2010care test for SCD is needed. The diagnostic accuracy of HemoTypeSC, a point\u2010of\u2010care immunoassay, for SCD was evaluated in individuals who had SCD, hemoglobin C disease, the related carrier (trait) states, or a normal hemoglobin phenotype. Children and adults participated in low\u2010, medium\u2010 and high\u2010resource environments (Ghana [<jats:italic>n<\/jats:italic> = 383], Martinique [<jats:italic>n<\/jats:italic> = 46], and USA [<jats:italic>n<\/jats:italic> = 158]). Paired blood specimens were obtained for HemoTypeSC and a reference diagnostic assay. HemoTypeSC testing was performed at the site of blood collection, and the reference test was performed in a laboratory at each site. In 587 participants, across all study sites, HemoTypeSC had an overall sensitivity of 99.5% and specificity of 99.9% across all hemoglobin phenotypes. The test had 100% sensitivity and specificity for sickle cell anemia. Sensitivity and specificity for detection of normal and trait states were &gt;99%. HemoTypeSC is an inexpensive (&lt;$2 per test), accurate, and rapid point\u2010of\u2010care test that can be used in resource\u2010limited regions with a high prevalence of SCD to provide timely diagnosis and support newborn screening programs.<\/jats:p>","DOI":"10.1002\/ajh.25305","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T09:50:22Z","timestamp":1538819422000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Point\u2010of\u2010care screening for sickle cell disease in low\u2010resource settings: A multi\u2010center evaluation of HemoTypeSC, a novel rapid test"],"prefix":"10.1002","volume":"94","author":[{"given":"Cindy","family":"Steele","sequence":"first","affiliation":[{"name":"Operation International Kids  Southampton New York"},{"name":"Children's Blood and Cancer Institute, Joseph M. Sanzari Children's Hospital  Hackensack New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Sinski","sequence":"additional","affiliation":[{"name":"Operation International Kids  Southampton New York"},{"name":"Children's Blood and Cancer Institute, Joseph M. Sanzari Children's Hospital  Hackensack New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Asibey","sequence":"additional","affiliation":[{"name":"Holy Family Hospital  Techiman Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Dominique","family":"Hardy\u2010Dessources","sequence":"additional","affiliation":[{"name":"Inserm UMR 1134, H\u00f4pital Ricou  Pointe\u2010\u00e0\u2010Pitre Guadeloupe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gis\u00e8le","family":"Elana","sequence":"additional","affiliation":[{"name":"Referral Center for Sickle Cell Disease Department of Pediatrics, University Hospital of Martinique  Martinique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Brennan","sequence":"additional","affiliation":[{"name":"Operation International Kids  Southampton New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Odame","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children, Department of Paediatrics University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology UCSF Benioff Children's Hospital Oakland  Oakland California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Geisberg","sequence":"additional","affiliation":[{"name":"Silver Lake Research Corporation  Azusa California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Serrao","sequence":"additional","affiliation":[{"name":"Silver Lake Research Corporation  Azusa California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2372-2175","authenticated-orcid":false,"given":"Charles T.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Division of Hematology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406093302303"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.33-5-195"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10937"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-435768"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25608"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-716910"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3758"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-233700"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24175"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.09.013"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61229-X"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1104"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-251348"},{"key":"e_1_2_6_15_1","unstructured":"United Nations General Assembly.63\/237. Recognition of sickle\u2010cell anaemia as a public health problem. Resolution Adopted by the General Assembly 2009.https:\/\/digitallibrary.un.org\/record\/644334"},{"key":"e_1_2_6_16_1","volume-title":"Uniting against NCDs: the time to act is now. The Brazzaville declaration on non\u2010communicable diseases prevention and control in the WHO African region","author":"World Health Organization","year":"2011"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.08.068"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-015-0222-8"},{"key":"e_1_2_6_19_1","unstructured":"Regional Committee for Africa.Sickle\u2010Cell Disease: a strategy for the WHO African Region.2011;60.http:\/\/www.who.int\/iris\/handle\/10665\/1682"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.08054.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.23.8.736"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3lc41302k"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0473-6"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24232"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-271"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3182-8"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2016.03.008"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14298"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1309\/YFVTUD0GHJF7D16H"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229680900300307"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.25305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.25305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T03:32:46Z","timestamp":1694662366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.25305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,31]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/ajh.25305"],"URL":"https:\/\/doi.org\/10.1002\/ajh.25305","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,31]]},"assertion":[{"value":"2018-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}