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However, allogeneic T cell therapies must address HLA barriers and conventionally rely on the availability of a suitable HLA\u2010matched donor if graft\u2010vs\u2010host\u2010disease and rejection effects are to be avoided. More recently, the incorporation of additional genome editing manipulations, to disrupt T cell receptor expression and address other critical pathways have been explored. Clinical trials are underway investigating non\u2010HLA matched T cells expressing anti\u2010CD19 CARs for the treatment of B cell acute lymphoblastic leukemia (B\u2010ALL) and anti\u2010CD123 CAR for acute myeloid leukemia (AML). 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