{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:37:42Z","timestamp":1778855862272,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Center for Clinical Research","award":["UL1 TR001855-04"],"award-info":[{"award-number":["UL1 TR001855-04"]}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"crossref","award":["1RO1HL136484-A1"],"award-info":[{"award-number":["1RO1HL136484-A1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"crossref","award":["1U01HL117718-01"],"award-info":[{"award-number":["1U01HL117718-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Although modern medical management has lowered overt stroke occurrence in patients with sickle cell disease (SCD), progressive white matter (WM) damage remains common. It is known that cerebral blood flow (CBF) increases to compensate for anemia, but sufficiency of cerebral oxygen delivery, especially in the WM, has not been systematically investigated. Cerebral perfusion was measured by arterial spin labeling in 32 SCD patients (age range: 10\u201042\u2009years old, 14 males, 7 with HbSC, 25 HbSS) and 25 age and race\u2010matched healthy controls (age range: 15\u201045\u2009years old, 10 males, 12 with HbAS, 13 HbAA); 8\/24 SCD patients were receiving regular blood transfusions and 14\/24 non\u2010transfused SCD patients were taking hydroxyurea. Imaging data from control subjects were used to calculate maps for CBF and oxygen delivery in SCD patients and their T\u2010score maps. Whole brain CBF was increased in SCD patients with a mean T\u2010score of 0.5 and correlated with lactate dehydrogenase (r<jats:sup>2<\/jats:sup>\u2009=\u20090.58, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). When corrected for oxygen content and arterial saturation, whole brain and gray matter (GM) oxygen delivery were normal in SCD, but WM oxygen delivery was 35% lower than in controls. Age and hematocrit were the strongest predictors for WM CBF and oxygen delivery in patients with SCD. There was spatial co\u2010localization between regions of low oxygen delivery and WM hyperintensities on T2 FLAIR imaging. To conclude, oxygen delivery is preserved in the GM of SCD patients, but is decreased throughout the WM, particularly in areas prone to WM silent strokes.<\/jats:p>","DOI":"10.1002\/ajh.25423","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T07:08:13Z","timestamp":1548832093000},"page":"467-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["White matter has impaired resting oxygen delivery in sickle cell patients"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-6720","authenticated-orcid":false,"given":"Yaqiong","family":"Chai","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Southern California Engineering School  Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam M.","family":"Bush","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University  California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Coloigner","sequence":"additional","affiliation":[{"name":"Univ Rennes, CNRS, Inria, Inserm, IRISA UMR 6074, VISAGES \u2013 ERL U 1228  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aart J.","family":"Nederveen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Academic Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benita","family":"Tamrazi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Children's Hospital Los Angeles  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chau","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Southern California Engineering School  Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program University of Southern California  Los Angeles California"},{"name":"Division of Cardiology Children's Hospital Los Angeles  Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9878-6029","authenticated-orcid":false,"given":"Thomas D.","family":"Coates","sequence":"additional","affiliation":[{"name":"Section of Hematology Children's Hospital Los Angeles  Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Lepore","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Southern California Engineering School  Los Angeles, California"},{"name":"Department of Radiology and Nuclear Medicine Children's Hospital Los Angeles  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-3439","authenticated-orcid":false,"given":"John C.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Southern California Engineering School  Los Angeles, California"},{"name":"Division of Cardiology Children's Hospital Los Angeles  Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,21]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: rates and risk factors","volume":"91","author":"Ohene\u2010Frempong K","year":"1998","journal-title":"Blood"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.117580"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1401731"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-261123"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-599852"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-694562"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05310.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.7404"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","unstructured":"ChaiY ColoignerJ QuX et al. 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