{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:25:05Z","timestamp":1790673905260,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 CA CA97274"],"award-info":[{"award-number":["P50 CA CA97274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Indolent B\u2010cell lymphomas other than follicular lymphoma account for up to 10% of all B\u2010cell neoplasms. While they typically follow a slowly progressive course, some patients experience rapid progression and early mortality. Prognostic scoring systems have not been adopted, hindering the ability of clinicians or researchers to predict outcomes, or risk\u2010stratify patients during clinical trials. To address this, we evaluated the utility of existing prognostic indices and novel, early disease\u2010related outcomes, to predict subsequent long term survival. Baseline characteristics and outcomes data were generated from a longitudinal cohort study that prospectively enrolled 632 patients newly diagnosed with marginal zone lymphoma, lymphoplasmacytic lymphomas, or B\u2010cell lymphomas not otherwise specified, beginning in 2002. The International Prognostic Index (IPI), Follicular Lymphoma International Prognostic Index (FLIPI), and MALT International prognostic index (MALT\u2010IPI) demonstrated c\u2010statistics that ranged from 0.593\u20100.612 for event\u2010free survival (EFS), and 0.683\u20100.714 for overall survival (OS). Patients who attained event\u2010free survival at 12\u2009months (EFS12) experienced similar mortality to the US general population (standardized mortality ratio [SMR] 1.19; 95% CI 0.95\u20101.46). Patients who did not attain EFS12 had subsequent worse morality (SMR 3.14 (95% CI 2.05\u20104.59). The MALT\u2010IPI demonstrated utility in predicting subsequent long\u2010term outcomes among patients with non\u2010follicular indolent B\u2010cell lymphomas. This index should be used by clinicians giving guidance to patients at the time of initial diagnosis, and risk stratification during clinical studies. The divergent long\u2010term outcomes experienced by patients who do or do not attain EFS12 suggest there exists a subset of patients who harbor high\u2010risk disease. Future research efforts should focus on methods to identify these patients at the time of diagnosis, in order to enable risk\u2010tailored therapy.<\/jats:p>","DOI":"10.1002\/ajh.25473","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:17:19Z","timestamp":1553732239000},"page":"658-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The utility of prognostic indices, early events, and histological subtypes on predicting outcomes in non\u2010follicular indolent B\u2010cell lymphomas"],"prefix":"10.1002","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-2589","authenticated-orcid":false,"given":"Sean I.","family":"Tracy","sequence":"first","affiliation":[{"name":"Division of Hematology, Oncology, and Bone Marrow Transplantation University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa C.","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne J.","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Slager","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C.","family":"Villasboas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristine","family":"Allmer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Habermann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umar","family":"Farooq","sequence":"additional","affiliation":[{"name":"Division Hematology, Oncology, and Bone Marrow Transplantation University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei","family":"Syrbu","sequence":"additional","affiliation":[{"name":"Division Hematology, Oncology, and Bone Marrow Transplantation University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7482-178X","authenticated-orcid":false,"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Link","sequence":"additional","affiliation":[{"name":"Division Hematology, Oncology, and Bone Marrow Transplantation University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"issue":"11","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V89.11.3909","article-title":"A clinical evaluation of the international lymphoma study group classification of non\u2010Hodgkin's lymphoma. 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