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For patients with disease limited to the skin, skin\u2010directed therapies are preferred, as both disease\u2010specific and overall survival for these patients is favorable. In contrast, patients with advanced\u2010stage disease with significant nodal, visceral or blood involvement are generally approached with systemic therapies. These include biologic\u2010response modifiers, histone deacetylase (HDAC) inhibitors, or antibody\u2010based strategies, in an escalating fashion. In highly\u2010selected patients, allogeneic stem\u2010cell transplantation may be considered, as this may be curative in some patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajh.25577","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T05:49:51Z","timestamp":1563342591000},"page":"1027-1041","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Mycosis fungoides and S\u00e9zary syndrome: 2019 update on diagnosis, risk\u2010stratification, and management"],"prefix":"10.1002","volume":"94","author":[{"given":"Alexandra C.","family":"Hristov","sequence":"first","affiliation":[{"name":"Departments of Pathology and Dermatology University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trilokraj","family":"Tejasvi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan Ann Arbor 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