{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:47:41Z","timestamp":1774529261170,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lower\u2010respiratory\u2010tract (LRT) amyloidosis has rarely been investigated. Our study presents characteristics, outcomes and survival of LRT amyloidosis. This multicenter retrospective study, from 1995 to 2017, included 73 patients with amyloidosis and LRT involvement. Respiratory patterns were: tracheobronchial (n = 17), nodular (n = 10), interstitial (n = 14) or composite (several respiratory involvements, n = 32). Interstitial and composite patterns were associated with multi\u2010organ amyloidosis (n = 37, 80%) while tracheobronchial and nodular patterns were associated with organ\u2010limited amyloidosis (n = 21, 78%). Amyloid light chain (AL) amyloidosis was diagnosed in 43 patients (59%), mainly of lambda type (n = 33, 77%). Smokers\u2019 proportion was higher in tracheobronchial (71%) and nodular (90%) patterns than in interstitial (14%) and composite (34%) patterns. The B\u2010cell neoplasms involved 15 patients (21%), solid neoplasms 8 (11%), connective tissue diseases 8 (11%) and multiple myeloma 6 (8%). The B\u2010cell and solid neoplasms were most prevalent in nodular pattern. Median follow\u2010up was 4.4\u2009years (2.2\u20108.9). Twenty\u2010four patients died, mostly from respiratory infection. Survival at 1, 5, 10\u2009years was respectively 88%, 70% and 54% for multi\u2010organ amyloidosis, 96%, 89% and 69% for organ\u2010limited amyloidosis (<jats:italic>P<\/jats:italic> =\u2009.125). Tracheobronchial and nodular patterns survival was better than in other respiratory patterns (<jats:italic>P<\/jats:italic> =\u2009.039). Death risk factors (multivariate analysis) were: cardiac localization (hazard\u2010ratio [HR] 4.3 [95% confidence interval 1.6\u201011.5]; <jats:italic>P<\/jats:italic> =\u2009.004), age (HR 2.1 [1.2\u20103.7]; <jats:italic>P<\/jats:italic> =\u2009.008) and dyspnea at diagnosis (HR 4.0 [1.3\u201012.3]; <jats:italic>P<\/jats:italic> =\u2009.014). Various LRT amyloidosis patterns depend on smoking habits, organ\u2010limited or multi\u2010organ extension and comorbidities. They are associated with a different survival, which is also predicted by age, cardiac localization and dyspnea at presentation.<\/jats:p>","DOI":"10.1002\/ajh.25608","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T06:11:14Z","timestamp":1565331074000},"page":"1214-1226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lower respiratory tract amyloidosis: Presentation, survival and prognostic factors. 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