{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T18:35:42Z","timestamp":1782758142525,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neutropenia (NP), that is, an absolute blood neutrophil count (ANC) &lt;1.5\u2009g\/L, accompanies various diseases. However, the clinical significance of NP, detected in routine complete blood cell counts (CBC) in primary care, is poorly characterized. Here, from a primary care resource with ANCs from &gt;370\u2009000 individuals, we identified and followed neutropenic subjects for the next 4\u2009years for novel ICD\u201010 based diagnoses of viral infections and hematological malignancies (ie, previously identified major outcomes in NP individuals) in Danish nationwide health registers. Risk estimates were assessed for children\/adolescents (1\u201018\u2009years) and adults (19\u201090\u2009years) in relation to NP severity, and for isolated NP, bi\u2010 or pancytopenias. We found that NP was observed in 4.9% of children and in 1.9% of adults. The lower the ANC, the likelier was a diagnosis of viral infections or hematological malignancies established during the ensuing 4\u2009years. Among neutropenic children, unspecified viral infections predominated, followed by mononucleosis (with other cytopenias in only 7% and 25% of the cases, respectively). All NP children with acute leukemia presented with bi\u2010 or pancytopenia from start of follow\u2010up. In NP adults, hepatitis, followed by HIV, were the most common infections, and acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDSs) the predominating hematological malignancies. Adult NP patients, subsequently diagnosed with hepatitis, HIV or AML, MDS, were bi\u2010 or pancytopenic in 42%, 47%, 90% and 91% of cases, respectively. Thus, presence of NP in even one CBC may be the first sign of a latent viral or hematological disorder requiring careful follow\u2010up.<\/jats:p>","DOI":"10.1002\/ajh.25756","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T09:53:40Z","timestamp":1581587620000},"page":"521-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Age\u2010related prevalence and clinical significance of neutropenia \u2010 isolated or combined with other cytopenias: Real world data from 373\u2009820 primary care individuals"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4014-2540","authenticated-orcid":false,"given":"Jan","family":"Palmblad","sequence":"first","affiliation":[{"name":"Department of Hematology and Medicine The Karolinska Institute at Karolinska University Hospital Huddinge  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkert","family":"Siersma","sequence":"additional","affiliation":[{"name":"The Research Unit for General Practice and Section of General Practice, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bent","family":"Lind","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Hvidovre  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Weis","family":"Bjerrum","sequence":"additional","affiliation":[{"name":"Department of Hematology Copenhagen University Hospital  Rigshospitalet Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hasselbalch","sequence":"additional","affiliation":[{"name":"Department of Hematology Roskilde University Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen Lykkegaard","family":"Andersen","sequence":"additional","affiliation":[{"name":"The Research Unit for General Practice and Section of General Practice, Department of Public Health University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Hematology Copenhagen University Hospital  Rigshospitalet Denmark"},{"name":"Department of Hematology Roskilde University Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-482612"},{"key":"e_1_2_7_3_1","unstructured":"National Cancer Institute.Common Toxicity Criteria for Adverse Events. 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