{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:44:27Z","timestamp":1789011867204,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T00:00:00Z","timestamp":1582934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The t(14;16) translocation, found in 3%\u20105% of newly diagnosed (ND) multiple myeloma (MM), has been associated with adverse outcomes. However, the studies establishing the characteristics of t(14;16) included solely small cohorts. The goal of the current international, multicenter (n = 25 centers), retrospective study was to describe the characteristics and outcomes of t(14;16) patients in a large, real\u2010world cohort (n = 223). A substantial fraction of patients had renal impairment (24%) and hemoglobin &lt;10 g\/dL (56%) on initial presentation. Combined therapy of both immunomodulatory drug and proteasome inhibitor (PI) in the first line was used in 35% of patients. Autologous stem cell transplantation was performed in 42% of patients. With a median follow up of 4.1\u2009years (95% CI 3.7\u201018.7), the median progression\u2010free survival (PFS) and overall survival (OS) from first line therapy were 2.1\u2009years (95% CI 1.5\u20102.4) and 4.1\u2009years (95% CI 3.3\u20105.5), respectively. Worse OS was predicted by age\u2009&gt;\u200960\u2009years (HR = 1.65, 95% CI [1.05\u20102.58]), as well as revised International Scoring System (R\u2010ISS) 3 (vs R\u2010ISS 2; HR = 2.59, 95% CI [1.59\u20104.24]). In conclusion, based on the largest reported cohort of t(14;16) patients, quarter of this subset of MM patients initially presents with renal failure, while older age and the R\u2010ISS 3 predict poor survival.<\/jats:p>","DOI":"10.1002\/ajh.25758","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T06:55:23Z","timestamp":1582095323000},"page":"503-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A multicenter retrospective study of 223 patients with t(14;16) in multiple myeloma"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8037-4269","authenticated-orcid":false,"given":"Sarah","family":"Goldman\u2010Mazur","sequence":"first","affiliation":[{"name":"Department of Hematology Jagiellonian University Medical College  Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-8365","authenticated-orcid":false,"given":"Artur","family":"Jurczyszyn","sequence":"additional","affiliation":[{"name":"Department of Hematology Jagiellonian University Medical College  Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9490-7532","authenticated-orcid":false,"given":"Jorge J.","family":"Castillo","sequence":"additional","affiliation":[{"name":"Division of Hematological Malignancies Dana\u2010Farber Cancer Institute, Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-1750","authenticated-orcid":false,"given":"Anna","family":"Waszczuk\u2010Gajda","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Internal Diseases Warsaw Medical University  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Grz\u0105\u015bko","sequence":"additional","affiliation":[{"name":"Department of Experimental Hematology Medical University of Lublin  Lublin Poland"},{"name":"Department of Hematology St. John\u02bcs Cancer Center  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-8238","authenticated-orcid":false,"given":"Jakub","family":"Radocha","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine\u2013 Hematology University Hospital and Faculty of Medicine in Hradec Kralove, Charles University  Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Bittrich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II University Hospital W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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