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Survivorship care model in cancers requiring a fixed\u2010duration therapy may not be applicable to myeloma, since patients are exposed to multiple lines of continuous therapy along the disease trajectory. The two most common therapy\u2010related causes of death, which require special consideration, are infection and second cancers. Identifying patients at a high risk of toxicities will facilitate individualized treatment selection and designing clinical trials for protective strategies targeting those patients. For example, prophylactic antibiotic or immunoglobulin replacement can be tested for primary prevention of infections in high\u2010risk patients. Long\u2010term follow up of ongoing trials and epidemiologic data will help identify the nature and trajectory of rare toxicities with a long latency, such as secondary cancers. Patients who are frail, have persistent renal insufficiency, and refractory to multiple lines of therapy need special attention regarding treatment toxicity and quality of life. In this review, we discuss the incidence, risk\u2010factors, and management of treatment and disease\u2010related complications in myeloma, discuss knowledge gaps and research priorities in this area, and propose a survivorship care model to improve health\u2010care delivery to a growing pool of myeloma survivors.<\/jats:p>","DOI":"10.1002\/ajh.25764","type":"journal-article","created":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T12:26:35Z","timestamp":1582374395000},"page":"672-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Treatment and disease\u2010related complications in multiple myeloma: Implications for survivorship"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-3003","authenticated-orcid":false,"given":"Rajshekhar","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Taussig Cancer Center Cleveland Clinic  Cleveland Ohio 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