{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:48:15Z","timestamp":1788925695348,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Patients with diffuse large B\u2010cell lymphoma (DLBCL) who fail to complete planned treatment with R\u2010CHOP due to toxicity are sparsely described. We investigated the extent of failure to complete treatment (six cycles or more, or three cycles + RT for patients with stage I disease) with R\u2010CHOP for reasons unrelated to non\u2010response, the determinants of such failure and the outcome among these patients. Three thousand one hundred and forty nine adult DLBCL patients who started primary treatment with R\u2010CHOP were identified through the Swedish lymphoma register 2007\u20102014. Of these, 147 (5%) stopped prematurely after 1\u20103 cycles of R\u2010CHOP for reasons unrelated to non\u2010response, 168 (5%) after 4\u20105 cycles and 2639 patients (84%) completed planned treatment. Additionally, 195 (6%) patients did not complete treatment due to non\u2010response or death before treatment end. In a multivariable logistic regression model, age\u2009&gt;\u200975\u2009years, poor performance status, extranodal disease and Charlson Comorbidity Index \u22651 were significantly associated with failure to complete planned R\u2010CHOP treatment for other reasons than non\u2010response. Non\u2010completion of treatment strongly correlated with survival. Five\u2010year overall survival for patients who received 1\u20103 cycles was 26% (95% CI: 19%\u201033%), 49% (95% CI: 41%\u201057%) for 4\u20105 cycles and 76% (74%\u201077%) for patients who completed treatment. Failure to complete planned R\u2010CHOP treatment is an important clinical issue associated with inferior survival. Old age and poor performance status most strongly predict such failure. These results indicate a need for improved treatment tailoring for patients with certain baseline demographics to improve tolerability and chance for treatment completion.<\/jats:p>","DOI":"10.1002\/ajh.25789","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T03:10:45Z","timestamp":1584414645000},"page":"740-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Outcome and determinants of failure to complete primary\n                    <scp>R\u2010CHOP<\/scp>\n                    treatment for reasons other than non\u2010response among patients with diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-0349","authenticated-orcid":false,"given":"Tove","family":"W\u00e4sterlid","sequence":"first","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Hematology Karolinska University Hospital  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Harrysson","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Hematology Karolinska University Hospital  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese M.\u2010L.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-467X","authenticated-orcid":false,"given":"Sara","family":"Ekberg","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Enblad","sequence":"additional","affiliation":[{"name":"Department of Oncology Akademiska University Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per\u2010Ola","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Hematology South \u00c4lvsborg Hospital  Bor\u00e5s Sweden"},{"name":"Sahlgrenska Academy Gothenburg University  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Jerkeman","sequence":"additional","affiliation":[{"name":"Department of Oncology and Pathology, Institute of Clinical Sciences Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-0573","authenticated-orcid":false,"given":"Sandra","family":"Eloranta","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin E.","family":"Smedby","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Hematology Karolinska University Hospital  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60313-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70122-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70235-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.1003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70664-7"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","unstructured":"Sehn HL et al. No added benefit of eight versus six cycles of CHOP when combined with rituximab in previously untreated diffuse large B\u2010cell lymphoma patients: results from the International Phase III GOYA study. Presented at: The ASH 60th Annual Meeting and Exposition; December 2018; San Diego CA.","DOI":"10.1182\/blood-2018-99-116845"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy184"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-112403"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.6929"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70002-0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24184"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-573089"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt058"},{"key":"e_1_2_6_16_1","volume-title":"Swedish Lymphoma Registry 2000\u20102012","author":"Jerkeman M","year":"2014"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2009.1.523"},{"key":"e_1_2_6_19_1","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe HN","year":"2001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(02)00585-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu210"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12889"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2014.01.008"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16049"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13619"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.05.006"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2095"}],"container-title":["American Journal of Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajh.25789","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.25789","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajh.25789","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajh.25789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T22:28:16Z","timestamp":1693952896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajh.25789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,3]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/ajh.25789"],"URL":"https:\/\/doi.org\/10.1002\/ajh.25789","archive":["Portico"],"relation":{},"ISSN":["0361-8609","1096-8652"],"issn-type":[{"value":"0361-8609","type":"print"},{"value":"1096-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,3]]},"assertion":[{"value":"2019-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}