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Although a huge body of evidence attests to the diagnostic utility of these assays, they have limitations that can render them unreliable in certain circumstances. Other assays are available for detecting LA but unfamiliarity, variable availability and technical concerns expressed in guidelines contribute to less usage than dRVVT and aPTT. However, assays such as Taipan snake venom time and Textarin time are insensitive to anticoagulants that compromise dRVVT and aPTT, and assays such as dilute prothrombin time can detect LA unreactive in dRVVT and aPTT. The pros and cons of alternative assays to dRVVT and APTT for LA detection are discussed.<\/jats:p>","DOI":"10.1002\/ajh.25836","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T17:02:13Z","timestamp":1587402133000},"page":"992-998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Alternative assays to <scp>dRVVT<\/scp> and <scp>aPTT<\/scp> for lupus anticoagulant detection"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2987-281X","authenticated-orcid":false,"given":"Gary W.","family":"Moore","sequence":"first","affiliation":[{"name":"Specialist Haemostasis Unit Addenbrooke's Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705454"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1606190"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12227"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13976"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03555.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP3J1ZKYBFQXJM"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2000.0414"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200404000-00015"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2012.09037.x"},{"key":"e_1_2_9_11_1","unstructured":"Ledford\u2010KraemerMR MooreGW BottenusR DanieleC deGrootPG ExnerT FavaloroEJ MoffatKA NicholsWL. 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