{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:45:34Z","timestamp":1785321934611,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T00:00:00Z","timestamp":1588896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Venous thromboembolic events (VTE) are a frequent complication of lymphoma. We conducted a retrospective analysis to compare VTE risk in diffuse large B\u2010cell lymphoma (DLBCL) and follicular lymphoma (FL). Subjects were randomly assigned to training and validation sets to identify risk factors of VTE and evaluate risk model performance, including the Khorana score. A group of 790 patients were diagnosed from 2002 to 2014 (DLBCL = 542, FL = 248). Median follow\u2010 up was 49\u2009months. We observed 106 VTE, with higher incidence in DLBCL (5\u2010year cumulative incidence = 16.3% vs 3.8% in FL patients). Five\u2010year OS for patients with VTE was 51.4% vs 73.1% in patients without VTE (<jats:italic>P<\/jats:italic> &lt;\u2009.001). Baseline VTE risk factors identified in the training cohort included lymphoma subtype, previous VTE, ECOG performance status \u22652, decreased albumin, increased calcium, elevated WBC, absolute lymphocyte count or monocyte count, and presence of bulky disease. Addition of new variables to the Khorana score improved its performance measured by Akaike information criterion and Concordance index. A new risk model including lymphoma subtype, albumin, WBC count, and bulky disease was validated in time\u2010based ROC analyses. These findings were confirmed in the validation cohort. Lymphoma subtypes have different VTE risk. The effect of lymphoma subtype was independent from disease burden and the use of systemic therapy. The Khorana risk\u2010score was validated in time to event analyses, and a more robust lymphoma\u2010specific VTE risk score is proposed. These findings suggest lymphoma patients with highest VTE risk can be identified with baseline parameters.<\/jats:p>","DOI":"10.1002\/ajh.25837","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T16:58:33Z","timestamp":1587401913000},"page":"918-926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Aggressive lymphoma subtype is a risk factor for venous thrombosis. Development of lymphoma \u2010 specific venous thrombosis prediction models"],"prefix":"10.1002","volume":"95","author":[{"given":"Gouri","family":"Dharmavaram","sequence":"first","affiliation":[{"name":"School of Medicine Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufen","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchitra","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Medicine Roswell Park Cancer Institute  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabarish","family":"Ayyappan","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Bone &amp; Marrow Transplantation University of Iowa  Iowa City Iowa 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Malignancies and Stem Cell Transplant Program, Division of Hematology and Oncology University Hospitals Seidman Cancer Center, Cleveland, Ohio and Case Comprehensive Cancer Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillard M.","family":"Lazarus","sequence":"additional","affiliation":[{"name":"Hematologic Malignancies and Stem Cell Transplant Program, Division of Hematology and Oncology University Hospitals Seidman Cancer Center, Cleveland, Ohio and Case Comprehensive Cancer Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Cooper","sequence":"additional","affiliation":[{"name":"Hematologic Malignancies and Stem Cell Transplant Program, Division of Hematology and Oncology University Hospitals Seidman Cancer Center, Cleveland, Ohio and Case Comprehensive Cancer Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingfu","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"de Lima","sequence":"additional","affiliation":[{"name":"Hematologic Malignancies and Stem Cell Transplant Program, Division of Hematology and Oncology University Hospitals Seidman Cancer Center, Cleveland, Ohio and Case Comprehensive Cancer Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1436-0464","authenticated-orcid":false,"given":"Paolo F.","family":"Caimi","sequence":"additional","affiliation":[{"name":"Hematologic Malignancies and Stem Cell Transplant Program, Division of Hematology and Oncology University Hospitals Seidman Cancer Center, Cleveland, Ohio and Case Comprehensive 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