{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:54:23Z","timestamp":1784836463305,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The optimal first\u2010line treatment for advanced\u2010stage Hodgkin's lymphoma (HL) is still a matter of debate. While ABVD is less toxic and as effective as other, more intensive chemotherapy regimens, escalated BEACOPP (BEACOPPesc) is superior to ABVD for initial disease control and prolonged time\u2010to\u2010relapse. However, this advantage is associated with higher rate of early and late toxicities. As most of these data have been accumulated from clinical trials, a retrospective analysis was conducted in a large database of patients treated outside clinical trials to investigate the advantages and disadvantages of these regimes in a real\u2010world setting. From October 2009 to October 2018, 397 advanced\u2010stage HL patients treated with either ABVD or BEACOPPesc were retrospectively assessed in 7 European cancer centers (2 Austrian and 5 Italian centers). Complete metabolic remission (CMR) by PET was achieved in 76% and 85% of patients in the ABVD and BEACOPPesc groups, respectively (<jats:italic>p<\/jats:italic>\u2009=\u2009.01). Severe adverse events occurred more frequently with BEACOPPesc than ABVD. At a median follow\u2010up of 8\u2009years, 9% of the patients who achieved CMR after BEACOPPesc relapsed compared to 16.6% in the ABVD group (<jats:italic>p<\/jats:italic> =\u2009.043). No statistical difference in progression free survival (PFS) was observed between the two cohorts overall (<jats:italic>p<\/jats:italic> =\u2009.11), but there was a trend towards a superior PFS in high\u2010risk patients treated with BEACOPPesc (<jats:italic>p<\/jats:italic> =\u2009.074). Nevertheless, overall survival was similar between the two groups (<jats:italic>p<\/jats:italic> =\u2009.94). In conclusion, we confirm that ABVD is an effective and less toxic therapeutic option for advanced\u2010stage HL. Although BEACOPP results in better initial tumor control, the long\u2010term outcome remains similar between the two regimens.<\/jats:p>","DOI":"10.1002\/ajh.25871","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T06:48:23Z","timestamp":1589784503000},"page":"1030-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<scp>ABVD<\/scp> vs <scp>BEACOPP<\/scp> escalated in advanced\u2010stage Hodgkin\u2019s lymphoma: Results from a multicenter European study"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-3757","authenticated-orcid":false,"given":"Patrizia","family":"Mondello","sequence":"first","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York NY"},{"name":"Department of Human Pathology University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Musolino","sequence":"additional","affiliation":[{"name":"Department of Human Pathology University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Dogliotti","sequence":"additional","affiliation":[{"name":"Hematology Division I, Department of Molecular Biotechnologies and Health Sciences University of Turin\/AOU \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2066-7377","authenticated-orcid":false,"given":"Jan\u2010Paul","family":"Bohn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Hematology Division I, Department of Molecular Biotechnologies and Health Sciences University of Turin\/AOU \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Hematology Division I, Department of Molecular Biotechnologies and Health Sciences University of Turin\/AOU \u201cCitt\u00e0 della Salute e della Scienza di Torino\u201d  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Botto","sequence":"additional","affiliation":[{"name":"Department of Hematology \u201cCitt\u00e0 della Salute e della Scienza Torino\u201d  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cerchione","sequence":"additional","affiliation":[{"name":"Hematology Unit Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Nappi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Hematology and Hematopoietic Stem Cell Transplant Center, University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya","family":"De Lorenzo","sequence":"additional","affiliation":[{"name":"Hematology and T.M.O.\u2010A.O.R.N. \u201cS. 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Moscati\u201d  Avellino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Hematology Unit Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Medical University of Innsbruck  Innsbruck Austria"},{"name":"Medical Clinic 3 University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Kepler University Hospital GmbH  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Loseto","sequence":"additional","affiliation":[{"name":"Hematology and Cell Therapy Unit IRCCS Cancer Institute \"Giovanni Paolo II\"  Bari 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