{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:43:02Z","timestamp":1790678582108,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["CA016672"],"award-info":[{"award-number":["CA016672"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hematol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Treatment of advanced\u2010phase chronic myeloid leukemia (CML) remains unsatisfactory. Single\u2010agent tyrosine kinase inhibitors have modest and short\u2010lived activity in this setting. We conducted a phase I\/II study to determine safety and efficacy of the combination of dasatinib and decitabine in patients with advanced CML. Two different dose schedules were investigated with a starting decitabine dose of either 10 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    or 20\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    daily for 10\u2009days plus dasatinib 100\u2009mg daily. The target dose level was decitabine 10 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    or 20\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    daily for 10\u2009days plus dasatinib 140\u2009mg daily. Thirty patients were enrolled, including seven with accelerated\u2010phase CML, 19 with blast\u2010phase CML, and four with Philadelphia\u2010chromosome positive acute myeloid leukemia. No dose\u2010limiting toxicity was observed at the starting dose level with either schedule. Grade \u22653 treatment emergent hematological adverse events were reported in 28 patients. Thirteen patients (48%) achieved a major hematologic response and six (22%) achieved a minor hematologic response, with 44% of these patients achieving a major cytogenetic response and 33% achieving a major molecular response. Median overall survival (OS) was 13.8 months, with significantly higher OS among patients who achieved a hematologic response compared to non\u2010responders (not reached vs 4.65\u2009months;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001). Decitabine plus dasatinib is a safe and active regimen in advanced CML. Further studies using this combination are warranted.\n                  <\/jats:p>","DOI":"10.1002\/ajh.25939","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T09:18:13Z","timestamp":1595063893000},"page":"1288-1295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Phase I\/II study of dasatinib in combination with decitabine in patients with accelerated or blast phase chronic myeloid leukemia"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-7912","authenticated-orcid":false,"given":"Yasmin","family":"Abaza","sequence":"first","affiliation":[{"name":"Department of Leukemia The University of Texas MD Anderson Cancer Center  Houston 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